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Application of Mesenchymal stem cells for therapeutic agent delivery in anti-tumor treatment

Неизвестный автор (2018)

© 2018 Chulpanova, Kitaeva, Tazetdinova, James, Rizvanov and Solovyeva. Mesenchymal stem cells (MSCs) are non-hematopoietic progenitor cells, which can be isolated from different types of tissues including bone marrow, ...
Cannabidiol prevents lipopolysaccharide-induced sickness behavior and alters cytokine and neurotrophic factor levels in the brain

Tito P.A.L.; Bernardino T.C.d.S.; Bellozi P.M.Q.; da Silva M.C.M.; de Miranda A.S.; Vieira É.L.M.; Moreira F.A.; Palotás A.; de Oliveira A.C.P.; Reis H.J. (2021)

Background: Major depressive disorder (MDD) affects millions of people worldwide. While the exact pathogenesis is yet to be elucidated, the role of neuro-immune signaling has recently emerged. Despite major advances in ...
∆ccr5 Genotype Is Associated with Mild Form of Nephropathia Epidemica

Kletenkov K.; Martynova E.; Davidyuk Y.; Kabwe E.; Shamsutdinov A.; Garanina E.; Shakirova V.; Khaertynova I.; Anokhin V.; Tarlinton R.; Rizvanov A.; Khaiboullina S.; Morzunov S. (2019)

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Nephropathia Epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) and linked to hantavirus infection, is endemic in the Republic of Tatarstan. ...
Cerebellar atrophy and changes in cytokines associated with the CACNA1A R583Q mutation in a Russian familial hemiplegic migraine type 1 family

Khaiboullina S.; Mendelevich E.; Shigapova L.; Shagimardanova E.; Gazizova G.; Nikitin A.; Martynova E.; Davidyuk Y.; Bogdanov E.; Gusev O.; Van Den Maagdenberg A.; Giniatullin R.; Rizvanov A. (2017)

© 2017 Khaiboullina, Mendelevich, Shigapova, Shagimardanova, Gazizova, Nikitin, Martynova, Davidyuk, Bogdanov, Gusev, van den Maagdenberg, Giniatullin and Rizvanov. Background: Immune mechanisms recently emerged as important ...
Computational intelligence technique for prediction of multiple sclerosis based on serum cytokines

Goyal M.; Khanna D.; Rana P.; Khaibullin T.; Martynova E.; Rizvanov A.; Khaiboullina S.; Baranwal M. (2019)

© 2019 Goyal, Khanna, Rana, Khaibullin, Martynova, Rizvanov, Khaiboullina and Baranwal. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution ...
Cytokine expression provides clues to the pathophysiology of Gulf War illness and myalgic encephalomyelitis

Khaiboullina S.; DeMeirleir K.; Rawat S.; Berk G.; Gaynor-Berk R.; Mijatovic T.; Blatt N.; Rizvanov A.; Young S.; Lombardi V. (2015)

© 2014 Elsevier Ltd. Gulf War illness (GWI) is a chronic disease of unknown etiology characterized by persistent symptoms such as cognitive impairment, unexplained fatigue, pervasive pain, headaches, and gastrointestinal ...
Cytokine Levels in the Serum of Patients with Chronic Kidney Insufficiency Before and After Hemodialysis

Romanova Y.; Markelova M.; Laikov A.; Fakhrutdinova L.; Hasanova M.; Malanin S.; Chernov V.; Salafutdinov I.; Khaiboullina S. (2017)

© 2016, Springer Science+Business Media New York.Chronic kidney insufficiency (CKI) is often the end point of a broad range of chronic kidney diseases and characterized with decreasing number of functionally active nephrons. ...
Enhanced angiogenic effects of RGD, GHK peptides and copper (II) compositions in synthetic cryogel ECM model

Zoughaib M.; Luong D.; Garifullin R.; Gatina D.Z.; Fedosimova S.V.; Abdullin T.I. (2021)

Synthetic oligopeptides are a promising alternative to natural full-length growth factors and extracellular matrix (ECM) proteins in tissue regeneration and therapeutic angiogenesis applications. In this work, angiogenic ...
Genetic modification of adipose derived stem cells with recombinant plasmid DNA pBud-VEGF-FGF2 results in increased of IL-8 and MCP-1 secretion

Solovyeva V.; Salafutdinov I.; Tazetdinova L.; Khaiboullina S.; Masgutov R.; Rizvanov A. (2014)

Bacterial plasmid DNA is often used in gene therapy application as a vector for delivering recombinant genes into eukaryotic cells. In this work we study effect of plasmid DNA encoding pro-angiogenic growth factors VEGF ...
Genetic Polymorphisms and Bacterial Infections in Neonates

Khaertynov K.; Anokhin V.; Rizvanov A.; Daviduk Y.; Lubin S. (2017)

© 2016, Springer Science+Business Media New York.Identifying single nucleotide polymorphisms (SNPs) in the genes involved in sepsis may help to clarify the pathophysiology of neonatal sepsis. The aim of this study was to ...
Granulocyte-macrophage colony-stimulating factor and car-t technology for solid tumors in experiment

Zaytsev D.V.; Zaikova E.K.; Golovkin A.S.; Bulatov E.R.; Valiullina A.K.; Mirgayazova R.M.; Daks A.A.; Zaritskey A.Y.; Petukhov A.V. (2020)

© 2020 Practical Medicine Publishing House. All rights reserved. Background. Cytokines are considered as important factors that enhance the efficacy of CAR-T cell therapy. Besides, they are key elements of the pathogenesis ...
Human adipose derived stem cells do not alter cytokine secretion in response to the genetic modification with pEGFP-N2 plasmid DNA

Solovyeva V.; Salafutdinov I.; Martynova E.; Khaiboullina S.; Rizvanov A. (2013)

Adipose tissue contain progenitor cells with regenerative (angiogenic, neuroprotection, trophic etc.) potential and treatment based on adipose tissue-derived stem cells (ADSCs) transplantation may constitute a promising ...
Inflammasomes as targets for adjuvants

Ivanov K.; Garanina E.; Rizvanov A.; Khaiboullina S. (2020)

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Inflammasomes are an essential part of the innate immune system. They are necessary for the development of a healthy immune response against infectious diseases. ...
Inflammasomes: Role in disease pathogenesis and therapeutic potential

Garanina E.E.; Martynova E.V.; Ivanov K.Y.; Rizvanov A.A.; Khaiboullina S.F. (2020)

© 2020 Kazan Federal University. All rights reserved. The structure of inflammasomes, history of their discovery, and their potential use as therapeutic targets were discussed. Inflammasomes represent cytosolic polyprotein ...
Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities

Неизвестный автор (2018)

© 2018 The Authors Acute myocardial infarction (AMI) and the heart failure that often follows, are major causes of death and disability worldwide. As such, new therapies are required to limit myocardial infarct (MI) size, ...
Markers of systemic inflammation in the pathogenesis of functional dyspesia

Неизвестный автор (2018)

© 2018, Pharmainfo Publications. All rights reserved. The article presents the results of research into the role of systemic inflammation in the pathogenesis and clinical presentation of functional dyspepsia. Elevated serum ...
Mechanisms of interacting Helicobacter pylori with gastric mucosal epithelium. II. A reaction of gastric epithelium on Helicobacter pylori colonization and persistence

Pozdeev O.; Pozdeeva A.; Valeeva Y.; Gulyaev P.; Savinova A. (2019)

© 2019 Saint Petersburg Pasteur Institute. All rights reserved. Gastric and duodenal recurrent inflammatory diseases have a high prevalence, but the role played by microbes in its development remained unclear. However, the ...
Multiplex analysis of serum cytokines in humans with hantavirus pulmonary syndrome

Morzunov S.; Khaiboullina S.; St. Jeor S.; Rizvanov A.; Lombardi V. (2015)

© 2015 Morzunov, Khaiboullina, St. Jeor, Rizvanov and Lombardi. Hantavirus pulmonary syndrome (HPS) is an acute zoonotic disease transmitted primarily through inhalation of virus-contaminated aerosols. Hantavirus infection ...
Multiplex Analysis of the Activation of the Immune System after Transection of the Rat’s Sciatic Nerve

Masgutova G.; Martynova E.; Masgutov R.; Mukhametova L.; Mullakhmetova A.; Kadyrova G.; Khaiboullina S.; Rizvanov A. (2017)

© 2016, Springer Science+Business Media New York.In this study, using the model of sciatic nerve transection in rats, the cytokine profile of peripheral blood serum and rat sciatic nerve fragments was measured 3, 7 and ...
Proangiogenic effect of 2A-peptide based multicistronic recombinant constructs encoding VEGF and FGF2 growth factors

Gatina D.Z.; Garanina E.E.; Zhuravleva M.N.; Synbulatova G.E.; Mullakhmetova A.F.; Solovyeva V.V.; Kiyasov A.P.; Rutland C.S.; Rizvanov A.A.; Salafutdinov I.I. (2021)

Coronary artery disease remains one of the primary healthcare problems due to the high cost of treatment, increased number of patients, poor clinical outcomes, and lack of effective therapy. Though pharmacological and ...

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