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Просмотр по автору "Umezawa Y."

Просмотр по автору "Umezawa Y."

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  • A systems model for immune cell interactions unravels the mechanism of inflammation in human skin 
    Valeyev N.; Hundhausen C.; Umezawa Y.; Kotov N.; Williams G.; Clop A.; Ainali C.; Ouzounis C.; Tsoka S.; Nestle F. (2010)
    Inflammation is characterized by altered cytokine levels produced by cell populations in a highly interdependent manner. To elucidate the mechanism of an inflammatory reaction, we have developed a mathematical model for ...
  • A systems model of phosphorylation for inflammatory signaling events 
    Sadreev I.; Chen M.; Welsh G.; Umezawa Y.; Kotov N.; Valeyev N. (2014)
    © 2014 Sadreev et al. Phosphorylation is a fundamental biochemical reaction that modulates protein activity in cells. While a single phosphorylation event is relatively easy to understand, multisite phosphorylation requires ...
  • Computational modelling elucidates the mechanism of ciliary regulation in health and disease 
    Kotov N.; Bates D.; Gizatullina A.; Gilaziev B.; Khairullin R.; Chen M.; Drozdov I.; Umezawa Y.; Hundhausen C.; Aleksandrov A.; Yan X.; Spurgeon S.; Smales C.; Valeyev N. (2011)
    Background: Ciliary dysfunction leads to a number of human pathologies, including primary ciliary dyskinesia, nephronophthisis, situs inversus pathology or infertility. The mechanism of cilia beating regulation is complex ...
  • Kinetic regulation of multi-ligand binding proteins 
    Salakhieva D.; Sadreev I.; Chen M.; Umezawa Y.; Evstifeev A.; Welsh G.; Kotov N. (2016)
    © 2016 Salakhieva et al.Background: Second messengers, such as calcium, regulate the activity of multisite binding proteins in a concentration-dependent manner. For example, calcium binding has been shown to induce ...
  • Systems biology of cell behavior 
    Valeyev N.; Bates D.; Umezawa Y.; Gizatullina A.; Kotov N. (2010)
    Systems Biology approaches to drug discovery largely focus on the increasing understanding of intracellular and cellular circuits, by computational representation of a molecular system followed by parameter validation ...
  • The competitive nature of signal transducer and activator of transcription complex formation drives phenotype switching of T cells 
    Sadreev I.; Chen M.; Umezawa Y.; Biktashev V.; Kemper C.; Salakhieva D.; Welsh G.; Kotov N. (2017)
    © 2017 John Wiley & Sons Ltd. Signal transducers and activators of transcription (STATs) are key molecular determinants of T-cell fate and effector function. Several inflammatory diseases are characterized by an altered ...

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