Browsing by Author "Martinez N."

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Dynamics of human acetylcholinesterase bound to non-covalent and covalent inhibitors shedding light on changes to the water network structure

Peters J.; Martinez N.; Trovaslet M.; Scannapieco K.; Koza M.; Masson P.; Nachon F. (2016)

© 2016 the Owner Societies.We investigated the effects of non-covalent reversible and covalent irreversible inhibitors on human acetylcholinesterase and human butyrylcholinesterase. Remarkably a non-covalent inhibitor, ...
Impact of sucrose as osmolyte on molecular dynamics of mouse acetylcholinesterase

Lushchekina S.V.; Inidjel G.; Martinez N.; Masson P.; Trovaslet-Leroy M.; Nachon F.; Koza M.M.; Seydel T.; Peters J. (2020)

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The enzyme model, mouse acetylcholinesterase, which exhibits its active site at the bottom of a narrow gorge, was investigated in the presence of different ...
Pressure-induced molten globule state of human acetylcholinesterase: Structural and dynamical changes monitored by neutron scattering

Marion J.; Trovaslet M.; Martinez N.; Masson P.; Schweins R.; Nachon F.; Trapp M.; Peters J. (2015)

© the Owner Societies 2015. We used small-angle neutron scattering (SANS) to study the effects of high hydrostatic pressure on the structure of human acetylcholinesterase (hAChE). At atmospheric pressure, our SANS results ...

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