Browsing by Author "Gabitova L."

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  • Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR 
    Gabitova L.; Restifo D.; Gorin A.; Manocha K.; Handorf E.; Yang D.; Cai K.; Klein-Szanto A.; Cunningham D.; Kratz L.; Herman G.; Golemis E.; Astsaturov I. (2015)
    © 2015 The Authors. Meiosis-activating sterols (MAS) are substrates of SC4MOL and NSDHL in the cholesterol pathway and are important for normal organismal development. Oncogenic transformation by epidermal growth factor ...
  • Molecular pathways: Sterols and receptor signaling in cancer 
    Gabitova L.; Gorin A.; Astsaturov I. (2014)
    Accelerated cholesterol and lipid metabolism are the hallmarks of cancer and contribute to malignant transformation due to the obligatory requirement for cholesterol for the function of eukaryotic membranes. To build new ...
  • Screening of conditionally reprogrammed patient-derived carcinoma cells identifies ERCC3-MYC interactions as a target in pancreatic cancer 
    Beglyarova N.; Banina E.; Zhou Y.; Mukhamadeeva R.; Andrianov G.; Bobrov E.; Lysenko E.; Skobeleva N.; Gabitova L.; Restifo D.; Pressman M.; Serebriiskii I.; Hoffman J.; Paz K.; Behrens D.; Khazak V.; Jablonski S.; Golemis E.; Weiner L.; Astsaturov I. (2016)
    ©2016 AACR.Purpose: Even when diagnosed prior to metastasis, pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with almost 90% lethality, emphasizing the need for new therapies optimally targeting the ...

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