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Просмотр по автору "Dobersch S."

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Epigenetics in lung cancer diagnosis and therapy

Mehta A.; Dobersch S.; Romero-Olmedo A.; Barreto G. (2015)

© 2015, Springer Science+Business Media New York. Lung cancer is the leading cause of cancer-related deaths worldwide. The initiation and progression of lung cancer is the result of the interaction between permanent genetic ...
Functional interactions between scaffold proteins, noncoding RNAs, and genome loci induce liquid-liquid phase separation as organizing principle for 3-dimensional nuclear architecture: implications in cancer

Rubio K.; Dobersch S.; Barreto G. (2019)

The eukaryotic cell nucleus consists of functionally specialized subcompartments. These nuclear subcompartments are biomolecular aggregates built of proteins, transcripts, and specific genome loci. The structure and function ...
Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis

Rubio K.; Singh I.; Dobersch S.; Sarvari P.; Günther S.; Cordero J.; Mehta A.; Wujak L.; Cabrera-Fuentes H.; Chao C.; Braubach P.; Bellusci S.; Seeger W.; Günther A.; Preissner K.; Wygrecka M.; Savai R.; Papy-Garcia D.; Dobreva G.; Heikenwalder M.; Savai-Pullamsetti S.; Braun T.; Barreto G. (2019)

© 2019, The Author(s). Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and highly lethal lung disease with unknown etiology and poor prognosis. IPF patients die within 2 years after diagnosis mostly due to ...
MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization

Singh I.; Contreras A.; Cordero J.; Rubio K.; Dobersch S.; Günther S.; Jeratsch S.; Mehta A.; Krüger M.; Graumann J.; Seeger W.; Dobreva G.; Braun T.; Barreto G. (2018)

© 2018 The Author(s). The majority of the eukaryotic genome is transcribed into noncoding RNAs (ncRNAs), which are important regulators of different nuclear processes by controlling chromatin structure. However, the full ...
Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate

Mehta A.; Cordero J.; Dobersch S.; Romero-Olmedo A.; Savai R.; Bodner J.; Chao C.; Fink L.; Guzmán-Díaz E.; Singh I.; Dobreva G.; Rapp U.; Günther S.; Ilinskaya O.; Bellusci S.; Dammann R.; Braun T.; Seeger W.; Gattenlöhner S.; Tresch A.; Günther A.; Barreto G. (2016)

© 2016 The Authors. Published under the terms of the CC BY 4.0 licenseLung cancer (LC) is the leading cause of cancer-related deaths worldwide. Early LC diagnosis is crucial to reduce the high case fatality rate of this ...
Pioneer Factors and Architectural Proteins Mediating Embryonic Expression Signatures in Cancer

Dobersch S.; Rubio K.; Barreto G. (2019)

© 2019 Elsevier Ltd Accumulation of mutations causing aberrant changes in the genome promotes cancer. However, mutations do not occur in every cancer subtype, suggesting additional events that trigger cancer. Chromatin ...
Validation of Tuba1a as appropriate internal control for normalization of gene expression analysis during mouse lung development

Mehta A.; Dobersch S.; Dammann R.; Bellusci S.; Ilinskaya O.; Braun T.; Barreto G. (2015)

© 2015 by the authors; licensee MDPI, Basel, Switzerland. The expression ratio between the analysed gene and an internal control gene is the most widely used normalization method for quantitative RT-PCR (qRT-PCR) expression ...

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