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  • Antitumor macrophage response to bacillus pumilus ribonuclease (Binase) 
    Makeeva A.; Rodriguez-Montesinos J.; Zelenikhin P.; Nesmelov A.; Preissner K.; Cabrera-Fuentes H.; Ilinskaya O. (2017)
    © Copyright 2017 Anna Makeeva et al. Extracellular bacterial ribonucleases such as binase from Bacillus pumilus possess cytotoxic activity against tumor cells with a potential for clinical application. Moreover, they may ...
  • Antitumor RNase (binase) induces the alteration of cellular permeability 
    Cabrera-Fuentes H.; Zelenikhin P.; Kolpakov A.; Ilinskaya O. (2012)
    Some RNases including ones of microbial origin possess antitumor activity, which mechanisms remains unclear. Here we investigated the first step of RNase action towards eukaryotic cells which is connected with increase of ...
  • Bacillus intermedius ribonuclease (BINASE) induces apoptosis in human ovarian cancer cells 
    Garipov A.; Nesmelov A.; Cabrera-Fuentes H.; Ilinskaya O. (2014)
    © 2014 Elsevier B.V. All rights reserved. The cytotoxic effects of Bacillus intermedius RNase (binase) towards ovarian cancer cells (SKOV3 and OVCAR5) were studied in comparison to normal ovarian epithelial cells (HOSE1 ...
  • Binase penetration into alveolar epithelial cells does not induce cell death 
    Cabrera-Fuentes H.; Kalacheva N.; Mukhametshina R.; Zelenikhin P.; Kolpakov A.; Barreto G.; Preissner K.; Ilinskaya O. (2012)
    Microbial ribonucleases possess a broad spectrum of biological activities, which demonstrate stimulating properties at low concentrations and cytotoxicity and genotoxicity at high concentrations. Mechanisms of their ...
  • Case report: Cyclospora cayetanensis: This emerging protozoan pathogen in Mexico 
    Śanchez-Vega J.; Cabrera-Fuentes H.; Romero-Olmedo A.; Ortiz-Fŕias J.; Sokolina F.; Barreto G. (2014)
    A Mexican airline pilot had clinical manifestations of illness after a five-day stay in Lima, Peru. Six months later in Mexico, he was given a diagnosis of infection with Cyclospora cayetanensis by using coproparasitoscopic ...
  • Circulating blood cells and extracellular vesicles in acute cardioprotection 
    Davidson S.; Andreadou I.; Barile L.; Birnbaum Y.; Cabrera-Fuentes H.; Cohen M.; Downey J.; Girao H.; Pagliaro P.; Penna C.; Pernow J.; Preissner K.; Ferdinandy P. (2019)
    Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com. During an ST-elevation myocardial infarction (STEMI), the ...
  • Diagnosis of Transient/Latent HPV Infections - A Point of View! 
    Perez-Campos Mayoral E.; Mayoral-Andrade G.; Pérez-Campos Mayoral L.; Canseco S.; Cruz R.; Hernández-Huerta M.; Rodriguez A.; Cabrera-Fuentes H.; Pérez-Campos E. (2018)
    © 2018 IMSS Diagnosis of transient/latent HPV infections requires a rethinking of ideas concerning the host virus relationship. With this in mind, we address several concepts, such as mutualism and commensalism, to understand ...
  • From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on “New frontiers in cardiovascular research” 
    Cabrera-Fuentes H.; Aragones J.; Bernhagen J.; Boening A.; Boisvert W.; Bøtker H.; Bulluck H.; Cook S.; Di Lisa F.; Engel F.; Engelmann B.; Ferrazzi F.; Ferdinandy P.; Fong A.; Fleming I.; Gnaiger E.; Hernández-Reséndiz S.; Kalkhoran S.; Kim M.; Lecour S.; Liehn E.; Marber M.; Mayr M.; Miura T.; Ong S.; Peter K.; Sedding D.; Singh M.; Suleiman M.; Schnittler H.; Schulz R.; Shim W.; Tello D.; Vogel C.; Walker M.; Li Q.; Yellon D.; Hausenloy D.; Preissner K. (2016)
    © 2016, The Author(s).In this meeting report, particularly addressing the topic of protection of the cardiovascular system from ischemia/reperfusion injury, highlights are presented that relate to conditioning strategies ...
  • Full left ventricular coverage is essential for the accurate quantification of the area-at-risk by T1 and T2 mapping 
    Bulluck H.; Bryant J.; Lim M.; Tan X.; Ramlall M.; Francis R.; Kotecha T.; Cabrera-Fuentes H.; Knight D.; Fontana M.; Moon J.; Hausenloy D. (2017)
    © 2017 The Author(s). T2-weighted cardiovascular magnetic resonance (CMR) using a 3-slice approach has been shown to accurately quantify the edema-based area-at-risk (AAR) in ST-segment elevation myocardial infarction ...
  • FURIN inhibition reduces vascular remodeling and atherosclerotic lesion progression in mice 
    Yakala G.; Cabrera-Fuentes H.; Crespo-Avilan G.; Rattanasopa C.; Burlacu A.; George B.; Anand K.; Mayan D.; Corlianò M.; Hernández-Reséndiz S.; Wu Z.; Schwerk A.; Tan A.; Trigueros-Motos L.; Chèvre R.; Chua T.; Kleemann R.; Liehn E.; Hausenloy D.; Ghosh S.; Singaraja R. (2019)
    © 2019 American Heart Association, Inc. Objective - Atherosclerotic coronary artery disease is the leading cause of death worldwide, and current treatment options are insufficient. Using systems-level network cluster ...
  • Hmga2 is required for canonical WNT signaling during lung development 
    Singh I.; Mehta A.; Contreras A.; Boettger T.; Carraro G.; Wheeler M.; Cabrera-Fuentes H.; Bellusci S.; Seeger W.; Braun T.; Barreto G. (2014)
    Background: The high-mobility-group (HMG) proteins are the most abundant non-histone chromatin-associated proteins. HMG proteins are present at high levels in various undifferentiated tissues during embryonic development ...
  • Immune cells as targets for cardioprotection: new players and novel therapeutic opportunities 
    Andreadou I.; Cabrera-Fuentes H.; Devaux Y.; Frangogiannis N.; Frantz S.; Guzik T.; Liehn E.; Gomes C.; Schulz R.; Hausenloy D. (2019)
    Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com. New therapies are required to reduce myocardial infarct ...
  • Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis 
    Rubio K.; Singh I.; Dobersch S.; Sarvari P.; Günther S.; Cordero J.; Mehta A.; Wujak L.; Cabrera-Fuentes H.; Chao C.; Braubach P.; Bellusci S.; Seeger W.; Günther A.; Preissner K.; Wygrecka M.; Savai R.; Papy-Garcia D.; Dobreva G.; Heikenwalder M.; Savai-Pullamsetti S.; Braun T.; Barreto G. (2019)
    © 2019, The Author(s). Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and highly lethal lung disease with unknown etiology and poor prognosis. IPF patients die within 2 years after diagnosis mostly due to ...
  • Influence of chronic food deprivation on structure-function relationship of juvenile rat fast muscles 
    Ruiz-Rosado A.; Cabrera-Fuentes H.; González-Calixto C.; González-López L.; Cázares-Raga F.; Segura-Alegría B.; Lochnit G.; De La Cruz Hernández-Hernández F.; Preissner K.; Jiménez-Estrada I. (2013)
    In the present study, we analyze the influence of chronic undernutrition on protein expression, muscle fiber type composition, and fatigue resistance of the fast extensor digitorum longus (EDL) muscle of male juvenile rats ...
  • Influence of extracellular rnas, released by rheumatoid arthritis synovial fibroblasts, on their adhesive and invasive properties 
    Zimmermann-Geller B.; Köppert S.; Fischer S.; Cabrera-Fuentes H.; Lefèvre S.; Rickert M.; Steinmeyer J.; Rehart S.; Umscheid T.; Schönburg M.; Muller-Ladner U.; Preissner K.; Frommer K.; Neumann E. (2016)
    © 2016 by The American Association of Immunologists, Inc.Extracellular RNA (exRNA) has been characterized as a molecular alarm signal upon cellular stress or tissue injury and to exert biological functions as a proinflammatory, ...
  • Innate immunity as a target for acute cardioprotection 
    Zuurbier C.; Abbate A.; Cabrera-Fuentes H.; Cohen M.; Collino M.; De Kleijn D.; Downey J.; Pagliaro P.; Preissner K.; Takahashi M.; Davidson S. (2019)
    Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com. Acute obstruction of a coronary artery causes myocardial ...
  • Internalization of Bacillus intermedius ribonuclease (BINASE) induces human alveolar adenocarcinoma cell death 
    Cabrera-Fuentes H.; Aslam M.; Saffarzadeh M.; Kolpakov A.; Zelenikhin P.; Preissner K.; Ilinskaya O. (2013)
    Ribonuclease (RNase) treatment represents a novel mechanism based approach to anticancer therapy as an alternative to the DNA damaging drugs commonly used in clinical practice. Apart from their ribonucleolytic activity, ...
  • Mechanism and consequences of the shift in cardiac arginine metabolism following ischaemia and reperfusion in rats 
    Schreckenberg R.; Weber P.; Cabrera-Fuentes H.; Steinert I.; Preissner K.; Bencsik P.; Sárközy M.; Csonka C.; Ferdinandy P.; Schulz R.; Schlüter K. (2016)
    © Schattauer 2015. Cardiac ischaemia and reperfusion leads to irreversible injury and subsequent tissue remodelling. Initial reperfusion seems to shift arginine metabolism from nitric oxide (NO) to polyamine formation. ...
  • Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside 
    Cabrera-Fuentes H.; Alba-Alba C.; Aragones J.; Bernhagen J.; Boisvert W.; Bøtker H.; Cesarman-Maus G.; Fleming I.; Garcia-Dorado D.; Lecour S.; Liehn E.; Marber M.; Marina N.; Mayr M.; Perez-Mendez O.; Miura T.; Ruiz-Meana M.; Salinas-Estefanon E.; Ong S.; Schnittler H.; Sanchez-Vega J.; Sumoza-Toledo A.; Vogel C.; Yarullina D.; Yellon D.; Preissner K.; Hausenloy D. (2016)
    © 2015, The Author(s). Recent advances in basic cardiovascular research as well as their translation into the clinical situation were the focus at the last “New Frontiers in Cardiovascular Research meeting”. Major topics ...
  • Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside 
    Cabrera-Fuentes H.; Alba-Alba C.; Aragones J.; Bernhagen J.; Boisvert W.; Bøtker H.; Cesarman-Maus G.; Fleming I.; Garcia-Dorado D.; Lecour S.; Liehn E.; Marber M.; Marina N.; Mayr M.; Perez-Mendez O.; Miura T.; Ruiz-Meana M.; Salinas-Estefanon E.; Ong S.; Schnittler H.; Sanchez-Vega J.; Sumoza-Toledo A.; Vogel C.; Yarullina D.; Yellon D.; Preissner K.; Hausenloy D. (2016)
    Recent advances in basic cardiovascular research as well as their translation into the clinical situation were the focus at the last "New Frontiers in Cardiovascular Research meeting". Major topics included the characterization ...

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