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Просмотр по автору "Astsaturov I."

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Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer

Gabitova-Cornell L.; Surumbayeva A.; Peri S.; Franco-Barraza J.; Restifo D.; Weitz N.; Ogier C.; Goldman A.R.; Hartman T.R.; Francescone R.; Tan Y.; Nicolas E.; Shah N.; Handorf E.A.; Cai K.Q.; O'Reilly A.M.; Sloma I.; Chiaverelli R.; Moffitt R.A.; Khazak V.; Fang C.Y.; Golemis E.A.; Cukierman E.; Astsaturov I. (2020)

© 2020 Elsevier Inc. Oncogenic transformation alters lipid metabolism to sustain tumor growth. We define a mechanism by which cholesterol metabolism controls the development and differentiation of pancreatic ductal ...
CRISPR/Cas9 Technique for Identification of Genes Regulating Oxaliplatin Resistance of Pancreatic Cancer Cell Line

Skripova V.; Serebriiskii I.; Abramova Z.; Astsaturov I.; Kiyamova R. (2017)

© 2016, Springer Science+Business Media New York.Genome editing approach based on prokaryotic CRISPR (clustered regularly interspaced short palindromic repeats) system is a simple and useful way to investigate gene functions ...
EGFR and RB1 as dual biomarkers in HPV-negative head and neck cancer

Beck T.; Georgopoulos R.; Shagisultanova E.; Sarcu D.; Handorf E.; Dubyk C.; Lango M.; Ridge J.; Astsaturov I.; Serebriiskii I.; Burtness B.; Mehra R.; Golemis E. (2016)

© 2016 American Association for Cancer Research.Clinical decision making for human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is predominantly guided by disease stage and anatomic location, ...
Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR

Gabitova L.; Restifo D.; Gorin A.; Manocha K.; Handorf E.; Yang D.; Cai K.; Klein-Szanto A.; Cunningham D.; Kratz L.; Herman G.; Golemis E.; Astsaturov I. (2015)

© 2015 The Authors. Meiosis-activating sterols (MAS) are substrates of SC4MOL and NSDHL in the cholesterol pathway and are important for normal organismal development. Oncogenic transformation by epidermal growth factor ...
Induction Therapy for Locally Advanced, Resectable Esophagogastric Cancer

Boland P.; Meyer J.; Berger A.; Cohen S.; Neuman T.; Cooper H.; Olszanski A.; Davey M.; Cheng J.; Lebenthal A.; Burtness B.; Scott W.; Astsaturov I. (2017)

© 2017 Wolters Kluwer Health, Inc. Preoperative chemotherapy and radiation for localized esophageal cancer produces cure rates near 30% when combined with surgical resection. Vandetanib, a small molecule receptor tyrosine ...
Induction Therapy for Locally Advanced, Resectable Esophagogastric Cancer: A Phase I Trial of Vandetanib (ZD6474), Paclitaxel, Carboplatin, 5-Fluorouracil, and Radiotherapy Followed by Resection

Boland P.; Meyer J.; Berger A.; Cohen S.; Neuman T.; Cooper H.; Olszanski A.; Davey M.; Cheng J.; Lebenthal A.; Burtness B.; Scott W.; Astsaturov I. (2016)

Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.OBJECTIVES:: Preoperative chemotherapy and radiation for localized esophageal cancer produces cure rates near 30% when combined with surgical resection. ...
Molecular pathways: Sterols and receptor signaling in cancer

Gabitova L.; Gorin A.; Astsaturov I. (2014)

Accelerated cholesterol and lipid metabolism are the hallmarks of cancer and contribute to malignant transformation due to the obligatory requirement for cholesterol for the function of eukaryotic membranes. To build new ...
Screening of conditionally reprogrammed patient-derived carcinoma cells identifies ERCC3-MYC interactions as a target in pancreatic cancer

Beglyarova N.; Banina E.; Zhou Y.; Mukhamadeeva R.; Andrianov G.; Bobrov E.; Lysenko E.; Skobeleva N.; Gabitova L.; Restifo D.; Pressman M.; Serebriiskii I.; Hoffman J.; Paz K.; Behrens D.; Khazak V.; Jablonski S.; Golemis E.; Weiner L.; Astsaturov I. (2016)

©2016 AACR.Purpose: Even when diagnosed prior to metastasis, pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with almost 90% lethality, emphasizing the need for new therapies optimally targeting the ...

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