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Browsing by Author "Salafutdinov I."

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A Genome-Wide Analysis of mRNA Expression in Human Tooth Germ Stem Cells Treated with Pluronic P85

Ataei A.; Solovyeva V.; Poorebrahim M.; Blatt N.; Salafutdinov I.; Şahin F.; Kiyasov A.; Yalvaç M.; Rizvanov A. (2016)

© 2016, Springer Science+Business Media New York.Human tooth germ stem cells (hTGSCs) originate from the neural crest and have a great potential to be used in stem cell therapies. Our group has previously shown that Pluronics ...
Adenoviral vector carrying glial cell-derived neurotrophic factor for direct gene therapy in comparison with human umbilical cord blood cell-mediated therapy of spinal cord injury in rat

Mukhamedshina Y.; Shaymardanova G.; Garanina; Salafutdinov I.; Rizvanov; Islamov R.; Chelyshev Y. (2015)

© 2015 International Spinal Cord Society Study design:Experimental study.Objective:To evaluate the treatment of spinal cord injury with glial cell-derived neurotrophic factor (GDNF) delivered using an adenoviral vector ...
Adenoviral vector carrying glial cell-derived neurotrophic factor for direct gene therapy in comparison with human umbilical cord blood cell-mediated therapy of spinal cord injury in rat

Mukhamedshina Y.; Shaymardanova G.; Garanina; Salafutdinov I.; Rizvanov; Islamov R.; Chelyshev Y. (2016)

© 2016 International Spinal Cord Society.Study design:Experimental study.Objective:To evaluate the treatment of spinal cord injury with glial cell-derived neurotrophic factor (GDNF) delivered using an adenoviral vector ...
Analysis of recombinant VEGF gene expression by genetically modified umbilical cord blood mononuclear cells in experiment in vivo

Mukhamedshina Y.; Solovieva V.; Salafutdinov I.; Cherenkova E.; Fedotova V.; Safiullov Z.; Izmailov A.; Sharifullina G.; Abdulhakov S.; Kaligin M.; Bashirov F.; Muhamediarov M.; Shmarov M.; Naroditskii B.; Kiiasov A.; Rizvanov A.; Islamov R. (2012)

To obtain a significant therapeutic effect transplanted genetically modified cells should have an enhanced ability to survive and active expression of the therapeutic gene. In this paper, by using immunofluorescent staining ...
Analysis of the efficiency of gene-cell therapy in transgenic mice with amyotrophic lateral sclerosis phenotype

Mukhamedyarov M.; Rizvanov A.; Safiullov Z.; Izmailov A.; Sharifullina G.; Solovieva V.; Fedotova V.; Salafutdinov I.; Cherenkova E.; Bashirov F.; Kaligin M.; Abdulkhakov S.; Shmarov M.; Logunov D.; Naroditsky B.; Kiyasov A.; Zefirov A.; Islamov R. (2013)

Amyotrophic lateral sclerosis is a neurodegenerative disease characterized by progressive death of cerebral and spinal motorneurons. Using behavioral tests we studied the efficiency of gene-cell therapy in SOD1 G93A ...
Angiogenesis and nerve regeneration induced by local administration of plasmid pBud-coVEGF165-coFGF2 into the intact rat sciatic nerve

Masgutov R.; Zeinalova A.; Bogov A.; Masgutova G.; Salafutdinov I.; Garanina E.; Syromiatnikova V.; Idrisova K.; Mullakhmetova A.; Andreeva D.; Mukhametova L.; Kadyrov A.; Pankov I.; Rizvanov A. (2021)

Vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) are well-known growth factors involved in the regeneration of various tissues and organs, including peripheral nerve system. In the present ...
Chromatographic purification of plasmid DNA for clinical applications (gene therapy)

Romanova J.; Salafutdinov I.; Zamalyutdinova N.; Rizvanov A. (2012)

For the successful application of plasmid vectors in gene therapy protocols it is necessary to develop methods for purification of highly homogeneous preparations of recombinant DNA that do not contain contaminants, primarily ...
Combination of epidural electrical stimulation with ex vivo triple gene therapy for spinal cord injury: A proof of principle study

Fadeev F.; Bashirov F.; Markosyan V.; Izmailov A.; Povysheva T.; Sokolov M.; Kuznetsov M.; Eremeev A.; Salafutdinov I.; Rizvanov A.; Lee H.; Islamov R. (2021)

Despite emerging contemporary biotechnological methods such as gene- and stem cell-based therapy, there are no clinically established therapeutic strategies for neural regeneration after spinal cord injury. Our previous ...
Combined treatment of throphic ulcer of the heel using vacuum therapy with direct gene therapy: Case report

Mullin R.; Masgutov R.; Salafutdinov I.; Rizvanov A.; Bogov A. (2013)

In this article we describe a clinical case of successful treatment of neurotrophic ulcers of heel region using classical surgical techniques such as debridement and autodermoplastics combined with vacuum therapy and ...
Construction of recombinant adenovirus containing picorna-viral 2A-peptide sequence for the co-expression of neuro-protective growth factors in human umbilical cord blood cells

Garanina E.; Mukhamedshina Y.; Salafutdinov I.; Kiyasov A.; Lima L.; Reis H.; Palotás A.; Islamov R.; Rizvanov A. (2015)

© 2015 International Spinal Cord Society Study design:Experimental study.Objective:Several neuro-degenerative disorders such as Alzheimer’s dementia, Parkinson’s disease and amyotrophic lateral sclerosis (ALS) are associated ...
Construction of recombinant adenovirus containing picorna-viral 2A-peptide sequence for the co-expression of neuro-protective growth factors in human umbilical cord blood cells

Garanina E.; Mukhamedshina Y.; Salafutdinov I.; Kiyasov A.; Lima L.; Reis H.; Palotás A.; Islamov R.; Rizvanov A. (2016)

© 2016 International Spinal Cord Society.Study design:Experimental study.Objective:Several neuro-degenerative disorders such as Alzheimer's dementia, Parkinson's disease and amyotrophic lateral sclerosis (ALS) are associated ...
Correction of the face soft tissue defect using autologous fat tissue enriched by cells of stromal-vascular fraction

Mastgutov R.; Rizvanov A.; Salafutdinov I.; Hannanova I.; Mullin R.; Bogov A.; Gallyamov A. (2012)

The article presents a clinical case of successful surgical treatment of a patient with idiopathic progressive hemifacial atrophy. We have used lipofilling with autologous fat tissue enriched by stromal-vascular fraction ...
Cytokine Levels in the Serum of Patients with Chronic Kidney Insufficiency Before and After Hemodialysis

Romanova Y.; Markelova M.; Laikov A.; Fakhrutdinova L.; Hasanova M.; Malanin S.; Chernov V.; Salafutdinov I.; Khaiboullina S. (2017)

© 2016, Springer Science+Business Media New York.Chronic kidney insufficiency (CKI) is often the end point of a broad range of chronic kidney diseases and characterized with decreasing number of functionally active nephrons. ...
Delivery of cord blood cells modified with adenoviral vectors expressing GDNF into the area of spinal cord injury stimulates recovery of motor function and supports a population of glial cells

Mukhamedshina Y.; Shaymardanova G.; Salafutdinov I.; Rizvanov A.; Povysheva T.; Masgutova G.; Nigmetzyanova M.; Chelyshev Y. (2013)

On the model of rat spinal cord dosed contusion at Th8 level studied the effect of delivery into the area of damage of glialcell- line-derived neurotrophic factor gene using adenovirustransduced of human umbilical cord ...
Differentiation and neuro-protective properties of immortalized human tooth germ stem cells

Yalvaç M.; Yilmaz A.; Mercan D.; Aydin S.; Dogan A.; Arslan A.; Demir Z.; Salafutdinov I.; Shafigullina A.; Sahin F.; Rizvanov A.; Palotás A. (2011)

Stem cells are considered to be promising therapeutic options in many neuro-degenerative diseases and injuries to the central nervous system, including brain ischemia and spinal cord trauma. Apart from the gold standard ...
Effects of transplantation of human cord blood mononuclear cells expressing the recombinant VEGF and FGF2 genes into spinal cord traumatic injury sites in rats

Shaimardanova G.; Mukhamedshina Y.; Rizvanov A.; Salafutdinov I.; Chelyshev Y. (2013)

A model of dosed TVIII spinal cord contusion trauma in rats was used to study the effects of immediate single-dose transplantation of human cord blood mononuclear cells transformed with the recombinant genes for neurotrophic ...
Effects of Transplanted Umbilical Cord Blood Mononuclear Cells Overexpressing GDNF on Spatial Memory and Hippocampal Synaptic Proteins in a Mouse Model of Alzheimer's Disease

Petukhova E.; Mukhamedshina Y.; Salafutdinov I.; Garanina E.; Kaligin M.; Leushina A.; Rizvanov A.; Reis H.; Palotás A.; Zefirov A.; Mukhamedyarov M. (2019)

© 2019 - IOS Press and the authors. All rights reserved. Background/Objective: Alzheimer's disease (AD) is a progressive incurable neurodegenerative disorder. Glial cell line-derived neurotrophic factor (GDNF) is a prominent ...
Epidural stimulation combined with triple gene therapy for spinal cord injury treatment

Islamov R.; Bashirov F.; Fadeev F.; Shevchenko R.; Izmailov A.; Markosyan V.; Sokolov M.; Kuznetsov M.; Davleeva M.; Garifulin R.; Salafutdinov I.; Nurullin L.; Chelyshev Y.; Lavrov I. (2020)

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The translation of new therapies for spinal cord injury to clinical trials can be facilitated with large animal models close in morpho-physiological scale to humans. ...
Gene-modified leucoconcentrate for personalized ex vivo gene therapy in a mini pig model of moderate spinal cord injury

Islamov R.; Bashirov F.; Sokolov M.; Izmailov A.; Fadeev F.; Markosyan V.; Davleeva M.; Zubkova O.; Smarov M.; Logunov D.; Naroditskyi B.; Salafutdinov I.; Rizvanov A.; Turaev R. (2021)

We previously demonstrated that gene-modified umbilical cord blood mononuclear cells overexpressing a combination of recombinant neurotrophic factors are a promising therapeutic approach for cell-mediated gene therapy for ...
Genetic modification of adipose derived stem cells with recombinant plasmid DNA pBud-VEGF-FGF2 results in increased of IL-8 and MCP-1 secretion

Solovyeva V.; Salafutdinov I.; Tazetdinova L.; Khaiboullina S.; Masgutov R.; Rizvanov A. (2014)

Bacterial plasmid DNA is often used in gene therapy application as a vector for delivering recombinant genes into eukaryotic cells. In this work we study effect of plasmid DNA encoding pro-angiogenic growth factors VEGF ...

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Browsing by Author "Salafutdinov I."

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