Browsing by Author "Mitkevich V."

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  • Binase cleaves cellular noncoding RNAs and affects coding mRNAs 
    Mitkevich V.; Tchurikov N.; Zelenikhin P.; Petrushanko I.; Makarov A.; Ilinskaya O. (2010)
    Bacterial RNases are promising tools for the development of anticancer drugs. Neoplastic transformation leads to enhanced accumulation of rRNA and tRNA, and altered expression of regulatory noncoding RNAs. Cleavage of RNA ...
  • Binase induces apoptosis of transformed myeloid cells and does not induce T-cell immune response 
    Ilinskaya O.; Zelenikhin P.; Petrushanko I.; Mitkevich V.; Prassolov V.; Makarov A. (2007)
    Microbial RNases along with such animal RNases as onconase and BS-RNase are a promising basis for developing new antitumor drugs. We have shown that the Bacillus intermedius RNase (binase) induces selective apoptosis of ...
  • Cell targets of antitumor ribonucleases 
    Mitkevich V.; Makarov A.; Ilinskaya O. (2014)
    Several ribonucleases (RNases) are known to exert a toxic effect on tumor cells, but the mechanism of their antitumor activity is still poorly understood. The review considers the RNase-cell component interaction that leads ...
  • Changing the net charge from negative to positive makes ribonuclease Sa cytotoxic 
    Ilinskaya O.; Dreyer F.; Mitkevich V.; Shaw K.; Nick Pace C.; Makarov A. (2002)
    Ribonuclease Sa (pI = 3.5) from Streptomyces aureofaciens and its 3K (D1K, D17K, E41K) (pI = 6.4) and 5K (3K + D25K, E74K) (pI = 10.2) mutants were tested for cytotoxicity. The 5K mutant was cytotoxic to normal and ...
  • Cytotoxicity of RNases is increased by cationization and counteracted by KCa channels 
    Ilinskaya O.; Koschinski A.; Mitkevich V.; Repp H.; Dreyer F.; Pace C.; Makarov A. (2004)
    KCa channels are involved in control of cell proliferation and differentiation. Here we have revealed their role in overcoming the RNase-induced cytotoxicity. Toxic effects of Streptomyces aureofaciens RNases Sa, Sa2, Sa3, ...
  • Oncogenic c-kit transcript is a target for binase 
    Mitkevich V.; Petrushanko I.; Kretova O.; Spirin P.; Zelenikhin P.; Prassolov V.; Tchurikov N.; Ilinskaya O.; Makarov A. (2010)
    Mutational activation of c-Kit receptor tyrosine kinase is common in acute myelogenous leukemia. One such activating point mutation is the N822K replacement in the c-Kit protein. Here we investigate the selective cytotoxic ...
  • Ribonuclease binase apoptotic signature in leukemic Kasumi-1 cells 
    Mitkevich V.; Kretova O.; Petrushanko I.; Burnysheva K.; Sosin D.; Simonenko O.; Ilinskaya O.; Tchurikov N.; Makarov A. (2013)
    Cytotoxic exogenous RNases triggering apoptotic response in malignant cells have potential as anticancer drugs; surprisingly, detailed characterization of the RNase-induced apoptosis has not been conducted so far. Here we ...
  • RNase-induced apoptosis: Fate of calcium-activated potassium channels 
    Ilinskaya O.; Koschinski A.; Repp H.; Mitkevich V.; Dreyer F.; Scholtz J.; Pace C.; Makarov A. (2008)
    The connection between the action of microbial RNases and Ca2+-activated K+ (KCa) channels was investigated in human embryo kidney cells HEKhSK4 artificially expressing the channels. These channels protected HEKhSK4 cells ...
  • Sensitivity of acute myeloid leukemia Kasumi-1 cells to binase toxic action depends on the expression of KIT and AML1-ETO oncogenes 
    Mitkevich V.; Petrushanko I.; Spirin P.; Fedorova T.; Kretova O.; Tchurikov N.; Prassolov V.; Ilinskaya O.; Makarov A. (2011)
    Some RNases selectively attack malignant cells, triggering an apoptotic response and therefore are considered as alternative chemotherapeutic drugs. Here, we studied the effects of Bacillus intermedius RNase (binase) on ...

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