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Browsing by Author "Markosyan V."

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Combination of epidural electrical stimulation with ex vivo triple gene therapy for spinal cord injury: A proof of principle study

Fadeev F.; Bashirov F.; Markosyan V.; Izmailov A.; Povysheva T.; Sokolov M.; Kuznetsov M.; Eremeev A.; Salafutdinov I.; Rizvanov A.; Lee H.; Islamov R. (2021)

Despite emerging contemporary biotechnological methods such as gene- and stem cell-based therapy, there are no clinically established therapeutic strategies for neural regeneration after spinal cord injury. Our previous ...
Combined supra-and sub-lesional epidural electrical stimulation for restoration of the motor functions after spinal cord injury in mini pigs

Fadeev F.; Eremeev A.; Bashirov F.; Shevchenko R.; Izmailov A.; Markosyan V.; Sokolov M.; Kalistratova J.; Khalitova A.; Garifulin R.; Islamov R.; Lavrov I. (2020)

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This study evaluates the effect of combined epidural electrical stimulation (EES) applied above (C5) and below (L2) the spinal cord injury (SCI) at T8–9 combined ...
Epidural stimulation combined with triple gene therapy for spinal cord injury treatment

Islamov R.; Bashirov F.; Fadeev F.; Shevchenko R.; Izmailov A.; Markosyan V.; Sokolov M.; Kuznetsov M.; Davleeva M.; Garifulin R.; Salafutdinov I.; Nurullin L.; Chelyshev Y.; Lavrov I. (2020)

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The translation of new therapies for spinal cord injury to clinical trials can be facilitated with large animal models close in morpho-physiological scale to humans. ...
Gene-modified leucoconcentrate for personalized ex vivo gene therapy in a mini pig model of moderate spinal cord injury

Islamov R.; Bashirov F.; Sokolov M.; Izmailov A.; Fadeev F.; Markosyan V.; Davleeva M.; Zubkova O.; Smarov M.; Logunov D.; Naroditskyi B.; Salafutdinov I.; Rizvanov A.; Turaev R. (2021)

We previously demonstrated that gene-modified umbilical cord blood mononuclear cells overexpressing a combination of recombinant neurotrophic factors are a promising therapeutic approach for cell-mediated gene therapy for ...
Preventive triple gene therapy reduces the negative consequences of ischemia-induced brain injury after modelling stroke in a rat

Markosyan V.; Safiullov Z.; Izmailov A.; Fadeev F.; Sokolov M.; Kuznetsov M.; Trofimov D.; Kim E.; Kundakchyan G.; Gibadullin A.; Salafutdinov I.; Nurullin L.; Bashirov F.; Islamov R. (2020)

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Currently, the main fundamental and clinical interest for stroke therapy is focused on developing a neuroprotective treatment of a penumbra region within the ...

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Browsing by Author "Markosyan V."

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