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Browsing by Author "Handorf E."

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Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients

Serebriiskii I.; Connelly C.; Frampton G.; Newberg J.; Cooke M.; Miller V.; Ali S.; Ross J.; Handorf E.; Arora S.; Lieu C.; Golemis E.; Meyer J. (2019)

© 2019, The Author(s). Colorectal cancer (CRC) is increasingly appreciated as a heterogeneous disease, with factors such as microsatellite instability (MSI), cancer subsite within the colon versus rectum, and age of diagnosis ...
EGFR and RB1 as dual biomarkers in HPV-negative head and neck cancer

Beck T.; Georgopoulos R.; Shagisultanova E.; Sarcu D.; Handorf E.; Dubyk C.; Lango M.; Ridge J.; Astsaturov I.; Serebriiskii I.; Burtness B.; Mehra R.; Golemis E. (2016)

© 2016 American Association for Cancer Research.Clinical decision making for human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is predominantly guided by disease stage and anatomic location, ...
Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR

Gabitova L.; Restifo D.; Gorin A.; Manocha K.; Handorf E.; Yang D.; Cai K.; Klein-Szanto A.; Cunningham D.; Kratz L.; Herman G.; Golemis E.; Astsaturov I. (2015)

© 2015 The Authors. Meiosis-activating sterols (MAS) are substrates of SC4MOL and NSDHL in the cholesterol pathway and are important for normal organismal development. Oncogenic transformation by epidermal growth factor ...
Genetic Variants That Predispose to DNA Double-Strand Breaks in Lymphocytes from a Subset of Patients with Familial Colorectal Carcinomas

Arora S.; Yan H.; Cho I.; Fan H.; Luo B.; Gai X.; Bodian D.; Vockley J.; Zhou Y.; Handorf E.; Egleston B.; Andrake M.; Nicolas E.; Serebriiskii I.; Yen T.; Hall M.; Golemis E.; Enders G. (2015)

© 2015 AGA Institute. Background & Aims DNA structural lesions are prevalent in sporadic colorectal cancer. Therefore, we proposed that gene variants that predispose to DNA double-strand breaks (DSBs) would be found in ...
Phospho-<sup>T356</sup>RB1 predicts survival in HPV-negative squamous cell carcinoma of the head and neck

Beck T.; Kaczmar J.; Handorf E.; Nikonova A.; Dubyk C.; Peri S.; Lango M.; Ridge J.; Serebriiskii I.; Burtness B.; Golemis E.; Mehra R. (2015)

Locally advanced squamous cell carcinoma of the head and neck (SCCHN) that is not associated with human papillomavirus (HPV) has a poor prognosis in contrast to HPV-positive disease. To better understand the importance of ...
Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer

Nicolas E.; Arora S.; Zhou Y.; Serebriiskii I.; Andrake M.; Handorf E.; Bodian D.; Vockley J.; Dunbrack R.; Ross E.; Egleston B.; Hall M.; Golemis E.; Giri V.; Daly M. (2015)

Risk assessment for prostate cancer is challenging due to its genetic heterogeneity. In this study, our goal was to develop an operational framework to select and evaluate gene variants that may contribute to familial ...

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Browsing by Author "Handorf E."

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