We have shown that polyclonal antibody IgG to native DNA leads to increased levels of apoptosis of nonuclear cells of healthy persons in vitro. Possible biological role of antibodies to DNA is discussed.

© 2017, Springer Science+Business Media, LLC, part of Springer Nature. Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex and largely unclear pathogenesis. Cellular phospholipid microvesicles released ...

© 2017, Springer Science+Business Media, LLC. Systemic lupus erythematosus (SLE) is an autoimmune disease associated with an increased risk of thrombosis. We hypothesized that inflammation-associated hyperfibrinogenemia ...

The data obtained on cell lines MDCK showed that for implementation of the biological function of antibodies to DNA both normal and pathological need the participation as Fab- and Fc-fragments of molecules of IgG. However, ...

Four fractions of IgG antibodies to native DNA (nDNA) were obtained from blood of patients with systemic lupus erythematosus. These antibodies displayed a thermostable DNA-hydrolyzing activity and were different in affinity ...

Two types of IgG anti-DNA antibodies exhibiting DNA-hydrolyzing activity have been isolated from blood serum of patients with systemic lupus erythematosus. This DNase activity of antibodies differs from serum DNases by the ...

© 2017, Springer Science+Business Media, LLC. Systemic lupus erythematosus (SLE) is an autoimmune disease in which the immune system mistakenly attacks multiple organs and tissues of the body. To elucidate the involvement ...