Since 1990s, when it was demonstrated by Hammel and others, that liver fibrosis is reversible, researchers and physicians actively search for new antifibrotic therapies. In recent years knowledge of liver fibrosis ...

Adenoviral transduction of hepatic stellate cells is applicable for short time stimulation of genes expression, safety for phenotype and cells proliferation. At the same time adenoviral transduction with growth factors ...

Restoration of liver after partial hepatectomy (PH) depends on proliferation dynamics of parenchymal and nonparenchymal liver cell populations. To study separately proliferation impact of nonparenchymal cells it is recommended ...

One of diabetes mellitus (DM) animal models is performed by injection of streptozocin-nicotinamide (SZC-NA) - agents that via GLUT-2 transporter blockage affect glucose transport into cells. GLUT-2 is highly present on ...

Due to lack of effective therapies, muscular dystrophies became a focus for gene therapy. Multiple pre-clinical studies have shown successful restoration of dystrofin and dysferlin by RNA editing both in vivo and in vitro, ...