dc.contributor.author |
Kameneva P. |
|
dc.contributor.author |
Artemov A.V. |
|
dc.contributor.author |
Kastriti M.E. |
|
dc.contributor.author |
Faure L. |
|
dc.contributor.author |
Olsen T.K. |
|
dc.contributor.author |
Otte J. |
|
dc.contributor.author |
Erickson A. |
|
dc.contributor.author |
Semsch B. |
|
dc.contributor.author |
Andersson E.R. |
|
dc.contributor.author |
Ratz M. |
|
dc.contributor.author |
Frisén J. |
|
dc.contributor.author |
Tischler A.S. |
|
dc.contributor.author |
de Krijger R.R. |
|
dc.contributor.author |
Bouderlique T. |
|
dc.contributor.author |
Akkuratova N. |
|
dc.contributor.author |
Vorontsova M. |
|
dc.contributor.author |
Gusev O. |
|
dc.contributor.author |
Fried K. |
|
dc.contributor.author |
Sundström E. |
|
dc.contributor.author |
Mei S. |
|
dc.contributor.author |
Kogner P. |
|
dc.contributor.author |
Baryawno N. |
|
dc.contributor.author |
Kharchenko P.V. |
|
dc.contributor.author |
Adameyko I. |
|
dc.date.accessioned |
2022-02-09T20:35:24Z |
|
dc.date.available |
2022-02-09T20:35:24Z |
|
dc.date.issued |
2021 |
|
dc.identifier.issn |
1061-4036 |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/169237 |
|
dc.description.abstract |
Characterization of the progression of cellular states during human embryogenesis can provide insights into the origin of pediatric diseases. We examined the transcriptional states of neural crest– and mesoderm-derived lineages differentiating into adrenal glands, kidneys, endothelium and hematopoietic tissue between post-conception weeks 6 and 14 of human development. Our results reveal transitions connecting the intermediate mesoderm and progenitors of organ primordia, the hematopoietic system and endothelial subtypes. Unexpectedly, by using a combination of single-cell transcriptomics and lineage tracing, we found that intra-adrenal sympathoblasts at that stage are directly derived from nerve-associated Schwann cell precursors, similarly to local chromaffin cells, whereas the majority of extra-adrenal sympathoblasts arise from the migratory neural crest. In humans, this process persists during several weeks of development within the large intra-adrenal ganglia-like structures, which may also serve as reservoirs of originating cells in neuroblastoma. |
|
dc.relation.ispartofseries |
Nature Genetics |
|
dc.title |
Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
5 |
|
dc.relation.ispartofseries-volume |
53 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
694 |
|
dc.source.id |
SCOPUS10614036-2021-53-5-SID85104053714 |
|