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Crystallization kinetics and glass-forming ability of rapidly crystallizing drugs studied by Fast Scanning Calorimetry

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dc.contributor.author Lapuk S.E.
dc.contributor.author Mukhametzyanov T.A.
dc.contributor.author Schick C.
dc.contributor.author Gerasimov A.V.
dc.date.accessioned 2022-02-09T20:34:02Z
dc.date.available 2022-02-09T20:34:02Z
dc.date.issued 2021
dc.identifier.issn 0378-5173
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/169066
dc.description.abstract The use of the amorphous forms of drugs is a modern approach for the enhancement of bioavailability. At the same time, the high cooling rate needed to obtain the metastable amorphous state often prevents its investigation using conventional laboratory methods such as differential scanning calorimetry, X-ray powder diffractometry. One of the ways to overcome this problem may be the application of Fast Scanning Calorimetry. This method allows direct determination of the critical cooling rate of the melt and kinetic parameters of the crystallization for bad glass formers. In the present work, the amorphous states of dopamine hydrochloride and atenolol were created using Fast Scanning Calorimetry for the first time. Critical cooling rates and glass transition temperatures of these drugs were determined. Based on the values of the kinetic fragility parameter, dopamine hydrochloride glass can be considered strong, while atenolol glass is moderately strong. Both model-based and model-free approaches were employed to determine the kinetic parameters of cold crystallization of dopamine and atenolol. The results were compared with the data from isothermal crystallization experiments. The Nakamura crystallization model provides the best description of the crystallization process and can be used to predict the long term stability of the amorphous forms of the drugs. The presented approaches may find applications in predicting the storage time and choosing the optimal storage conditions of the amorphous drugs prone to crystallization.
dc.relation.ispartofseries International Journal of Pharmaceutics
dc.subject Calorimetry
dc.subject Drug
dc.subject Glass
dc.subject Kinetic fragility crystallization
dc.subject Kinetics
dc.subject Stability
dc.subject Thermal analysis
dc.title Crystallization kinetics and glass-forming ability of rapidly crystallizing drugs studied by Fast Scanning Calorimetry
dc.type Article
dc.relation.ispartofseries-volume 599
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS03785173-2021-599-SID85102100114


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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