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LIOFeron®TB/LTBI: A novel and reliable test for LTBI and tuberculosis

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dc.contributor.author Della Bella C.
dc.contributor.author Spinicci M.
dc.contributor.author Alnwaisri H.F.M.
dc.contributor.author Bartalesi F.
dc.contributor.author Tapinassi S.
dc.contributor.author Mencarini J.
dc.contributor.author Benagiano M.
dc.contributor.author Grassi A.
dc.contributor.author D'Elios S.
dc.contributor.author Troilo A.
dc.contributor.author Abilbayeva A.
dc.contributor.author Kuashova D.
dc.contributor.author Bitanova E.
dc.contributor.author Tarabayeva A.
dc.contributor.author Shuralev E.A.
dc.contributor.author Bartoloni A.
dc.contributor.author D'Elios M.M.
dc.date.accessioned 2021-02-25T20:39:06Z
dc.date.available 2021-02-25T20:39:06Z
dc.date.issued 2020
dc.identifier.issn 1201-9712
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/162177
dc.description.abstract © 2019 The Author(s) Objectives: High accuracy diagnostic screening tests for tuberculosis (TB) are required to improve the diagnosis of both active TB and latent Mycobacterium tuberculosis (MTB) infection (LTBI). The novel IGRA LIOFeron®TB/LTBI assay was tested and its accuracy was compared to the QuantiFERON®-TB Gold Plus assay. Methods: A total of 389 subjects were enrolled in two cohorts and classified as healthy, active TB or LTBI persons. The blood of all the patients was tested with LIOFeron®TB/LTBI assay, containing MTB alanine dehydrogenase, able to differentiate active TB from LTBI diagnosis. The results obtained with both IGRAs, performed on the same 250 samples, were finally compared. Results: The two assays demonstrated an excellent concordance of their results with patients’ diagnosis of MTB infection. ROC analysis for QuantiFERON®-TB Gold Plus showed sensitivity and specificity respectively of 98% and 97% in diagnosing active TB patients and 85% and 94% in diagnosing LTBI subjects. LIOFeron®TB/LTBI assay showed sensitivity and specificity respectively of 90% and 98% in diagnosing active TB patients and 94% and 97% in diagnosing LTBI subjects. Conclusions: The two IGRAs displayed the same high accuracy in diagnosing MTB infection/TB disease, and LIOFeron®TB/LTBI assay demonstrated higher sensitivity than QuantiFERON®-TB Gold Plus test in LTBI detection.
dc.relation.ispartofseries International Journal of Infectious Diseases
dc.subject Alanine dehydrogenase
dc.subject IGRA
dc.subject Mycobacterium tuberculosis
dc.subject Tuberculosis diagnosis
dc.title LIOFeron®TB/LTBI: A novel and reliable test for LTBI and tuberculosis
dc.type Article
dc.relation.ispartofseries-volume 91
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 177
dc.source.id SCOPUS12019712-2020-91-SID85076676646


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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