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Activation Markers and Regulatory T cells in Children with Chronic Pyelonephritis Associated with Bacterial Uropathogens

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dc.contributor.author Agafonova E.
dc.contributor.author Rizvanova F.
dc.contributor.author Malanicheva T.
dc.contributor.author Abrahamyan L.
dc.date.accessioned 2020-01-15T22:13:06Z
dc.date.available 2020-01-15T22:13:06Z
dc.date.issued 2019
dc.identifier.issn 2191-1630
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/157107
dc.description.abstract © 2019, Springer Science+Business Media, LLC, part of Springer Nature. The expression of activation markers on lymphocytes and a subpopulation of regulatory T cells (CD4+ CD25+ Hi) were evaluated in children with chronic pyelonephritis. We have distinguished the following clinical variants of pathology: dysmetabolic, obstructive, and mixed (obstructive dysmetabolic) chronic pyelonephritis. Flow cytofluorometry was used to evaluate the population and subpopulations of T lymphocytes expressing CD3+HLA-DR+ and CD8+HLA-DR+ class II histocompatibility antigens, CD95−СD3+CD95+ activation apoptosis marker, subpopulations expressing the homing receptor CD4+CD62L+ and CD4+CD62L−, and subpopulations of CD4+CD25+Hi regulatory T cells (Treg). In dysmetabolic variants of chronic pyelonephritis, an activation profile of lymphocytes is characterized mainly by positive activation and the subpopulation of CD4+ lymphocytes, forming an increase in the content of effectors/activated cells with enhanced migration into the target organ. In the case of obstructive variants of chronic pyelonephritis, antigen-mediated activation and an increase in the pool of activated cytotoxic T lymphocytes (CD8+HLA-DR+) result in activation-induced apoptosis and cell death, leading to leukopenia and lymphopenia. Expansion of regulatory T cells (CD4+CD25+ Hi) in obstructive variants of chronic pyelonephritis can be considered a factor regulating apoptosis in the process of long-term activation of T lymphocytes.
dc.relation.ispartofseries BioNanoScience
dc.subject Apoptosis
dc.subject Children
dc.subject Chronic pyelonephritis
dc.subject Lymphocyte activation markers
dc.subject Regulatory T cells
dc.title Activation Markers and Regulatory T cells in Children with Chronic Pyelonephritis Associated with Bacterial Uropathogens
dc.type Article
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS21911630-2019-SID85075869093


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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