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Biocompatibility and therapeutic potential of glycosylated albumin artificial metalloenzymes

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dc.contributor.author Eda S.
dc.contributor.author Nasibullin I.
dc.contributor.author Vong K.
dc.contributor.author Kudo N.
dc.contributor.author Yoshida M.
dc.contributor.author Kurbangalieva A.
dc.contributor.author Tanaka K.
dc.date.accessioned 2020-01-15T22:06:57Z
dc.date.available 2020-01-15T22:06:57Z
dc.date.issued 2019
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/156644
dc.description.abstract © 2019, The Author(s), under exclusive licence to Springer Nature Limited. The ability of natural metalloproteins to prevent inactivation of their metal cofactors by biological metabolites, such as glutathione, is an area that has been largely ignored in the field of artificial metalloenzyme (ArM) development. Yet, for ArM research to transition into future therapeutic applications, biocompatibility remains a crucial component. The work presented here shows the creation of a human serum albumin-based ArM that can robustly protect the catalytic activity of a bound ruthenium metal, even in the presence of 20 mM glutathione under in vitro conditions. To exploit this biocompatibility, the concept of glycosylated artificial metalloenzymes (GArM) was developed, which is based on functionalizing ArMs with N-glycan targeting moieties. As a potential drug therapy, this study shows that ruthenium-bound GArM complexes could preferentially accumulate to varying cancer cell lines via glycan-based targeting for prodrug activation of the anticancer agent umbelliprenin using ring-closing metathesis.
dc.title Biocompatibility and therapeutic potential of glycosylated albumin artificial metalloenzymes
dc.type Article
dc.relation.ispartofseries-issue 9
dc.relation.ispartofseries-volume 2
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 780
dc.source.id SCOPUS-2019-2-9-SID85068560036


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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