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2(5H)-Furanone Derivatives as Inhibitors of Staphylococcal Biofilms

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dc.contributor.author Trizna E.
dc.contributor.author Latypova L.
dc.contributor.author Kurbangalieva A.
dc.contributor.author Bogachev M.
dc.contributor.author Kayumov A.
dc.date.accessioned 2018-09-19T23:10:52Z
dc.date.available 2018-09-19T23:10:52Z
dc.date.issued 2016
dc.identifier.issn 2191-1630
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/146015
dc.description.abstract © 2016, Springer Science+Business Media New York.The opportunistic bacteria Staphylococcus aureus and Staphylococcus epidermidis often form rigid biofilms on wounds and artificial surfaces and thereby become extremely resistant to antimicrobials. Here, we report the effect of four novel 2(5H)-furanone derivatives on the cell growth and biofilm formation by these microorganisms. Using the differential fluorescence staining of viable and dead cells, we demonstrated that furanones increase the antibacterial efficacy of chloramphenicol against both biofilm-embedded S. aureus and S. epidermidis with F35 being the most efficient compound, probably by increasing the accessibility of cells against antimicrobials. Compounds F6, F8, and F83 inhibited the biofilm formation at concentrations of 2.5–10 μg/ml, although exhibiting high cytotoxicity for human skin fibroblasts with CC50 of 0.5–1.1 μg/ml. F35 demonstrated minimal biofilm inhibition concentration of 10 μg/ml, while its cytotoxicity was ten times lower than that of the other compounds (CC50 13.1 μg/ml), suggesting its chemotype seems a promising starting point for the development of new antibiofilm agents.
dc.relation.ispartofseries BioNanoScience
dc.subject 2(5H)-furanones
dc.subject Antibacterial activity
dc.subject Biofilms
dc.subject S. aureus
dc.subject S. epidermidis
dc.subject Unsaturated lactones
dc.title 2(5H)-Furanone Derivatives as Inhibitors of Staphylococcal Biofilms
dc.type Article
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 6
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 423
dc.source.id SCOPUS21911630-2016-6-4-SID84999635716


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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