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Combined action of binase and bleomycin toward human lung adenocarcinoma cells

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dc.contributor.author Zelenikhin P.
dc.contributor.author Makeeva A.
dc.contributor.author Nguen T.
dc.contributor.author Siraj Y.
dc.contributor.author Ilinskaya O.
dc.date.accessioned 2018-09-19T23:02:40Z
dc.date.available 2018-09-19T23:02:40Z
dc.date.issued 2016
dc.identifier.issn 2310-6905
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/145927
dc.description.abstract Some microbial ribonucleases (RNases) demonstrate selective cytotoxic effect against a wide range of tumor cells. In this context combined use of cytotoxic RNases in complex therapy with other chemotherapeutic agents appears to be especially promising. In this study we have investigated the apoptosis-induced effect of Bacillus pumilus RNase (binase) in combination with known anti-tumor antibiotic bleomycin on human lung adenocarcinoma A549 cells. The combined effect of high concentrations of these agents did not have any mutual increase in their apoptosis-induced action, while a combination of non-apoptotic concentrations resulted in the increase of the proportion of apoptotic cells up to 22% as compared with individual effect of bleomycin (6%) and binase (12%) used separately. These results indicate that binase and bleomycin are effective in combination of their low concentrations and ineffective in combination of their high concentrations.
dc.relation.ispartofseries Biomeditsinskaya Khimiya
dc.subject Antitumor activity
dc.subject Bacillus pumilus
dc.subject Binase
dc.subject Bleomycin
dc.subject Cytotoxic ribonucleases
dc.subject Lung adenocarcinoma
dc.title Combined action of binase and bleomycin toward human lung adenocarcinoma cells
dc.type Article
dc.relation.ispartofseries-issue 3
dc.relation.ispartofseries-volume 62
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 279
dc.source.id SCOPUS23106905-2016-62-3-SID84997113361


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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