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NMR structure, conformational dynamics, and biological activity of PsDef1 defensin from Pinus sylvestris

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dc.contributor.author Khairutdinov B.
dc.contributor.author Ermakova E.
dc.contributor.author Yusypovych Y.
dc.contributor.author Bessolicina E.
dc.contributor.author Tarasova N.
dc.contributor.author Toporkova Y.
dc.contributor.author Kovaleva V.
dc.contributor.author Zuev Y.
dc.contributor.author Nesmelova I.
dc.date.accessioned 2018-09-19T21:29:53Z
dc.date.available 2018-09-19T21:29:53Z
dc.date.issued 2017
dc.identifier.issn 1570-9639
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/144060
dc.description.abstract © 2017 Elsevier B.V.Plants have developed a complex defense response system against pests and pathogens. Defensins, produced by plants as part of their innate immune response, form the family of small, basic, cysteine-rich proteins with activity primarily directed against fungal pathogens. In addition, plant defensins can show antibacterial activity and protease and insect amylase inhibitory activities. However, in gymnosperms, only antifungal activity of defensins has been described thus far. Here, we report antibacterial and insect α-amylase inhibition activities for defensin PsDef1 from P. sylvestris, the first defensin from gymnosperms with a broad range of biological activities described. We also report the solution NMR structure of PsDef1 and its dynamics properties assessed by a combination of experimental NMR and computational techniques. Collectively, our data provide an insight into structure, dynamics, and functional properties of PsDef1 that could be common between defensins from this taxonomic group.
dc.relation.ispartofseries Biochimica et Biophysica Acta - Proteins and Proteomics
dc.subject Amylase inhibition
dc.subject Antibacterial activity
dc.subject Conformational dynamics
dc.subject NMR structure
dc.subject Plant defensin
dc.subject Scotts pine defensin
dc.title NMR structure, conformational dynamics, and biological activity of PsDef1 defensin from Pinus sylvestris
dc.type Article
dc.relation.ispartofseries-issue 8
dc.relation.ispartofseries-volume 1865
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 1085
dc.source.id SCOPUS15709639-2017-1865-8-SID85020012286


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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