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Novel type of isoprenoid membrane anchors: An investigation of binding properties with dipalmitoylphosphatidylcholine vesicles

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dc.contributor.author Faizullin D.
dc.contributor.author Dzyurkevich M.
dc.contributor.author Valiullina Y.
dc.contributor.author Islamov D.
dc.contributor.author Kataeva O.
dc.contributor.author Zuev Y.
dc.contributor.author Plemenkov V.
dc.contributor.author Stoikov I.
dc.date.accessioned 2018-09-19T20:38:03Z
dc.date.available 2018-09-19T20:38:03Z
dc.date.issued 2016
dc.identifier.issn 0894-3230
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/143074
dc.description.abstract © 2016 John Wiley & Sons, Ltd.In this work, we present a new type of amphiphilic membrane-anchoring agents that can be easily obtained by the Diels-Alder reaction between terpene myrcene and N-substituted maleimides. The interaction between the compounds and small unilamellar dipalmitoylphosphatidylcholine vesicles was investigated using infrared spectroscopy, microgravimetry, and turbidimetry. The ability of the compounds to embed in the phospholipid membrane was shown to be strongly dependent on the charge of their polar group. The insertion of the compounds studied into the lipid bilayer did not lead to disruption of the dipalmitoylphosphatidylcholine vesicles up to the highest tested drug to lipid molar ratio of 0.5 to 0.6. Low lipid solubilization ability of the compounds as well as their rigid nonplanar structure makes them an interesting alternative to the common membrane-anchoring structural motifs.
dc.relation.ispartofseries Journal of Physical Organic Chemistry
dc.subject Dipalmitoylphosphatidylcholine vesicles
dc.subject Membrane anchors
dc.subject N-substituted maleimides
dc.subject Terpenoids
dc.title Novel type of isoprenoid membrane anchors: An investigation of binding properties with dipalmitoylphosphatidylcholine vesicles
dc.type Article in Press
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS08943230-2016-SID84981309778


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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