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Structure of the 70S ribosome from human pathogen Staphylococcus aureus

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dc.contributor.author Khusainov I.
dc.contributor.author Vicens Q.
dc.contributor.author Bochler A.
dc.contributor.author Grosse F.
dc.contributor.author Myasnikov A.
dc.contributor.author Meńetret J.
dc.contributor.author Chicher J.
dc.contributor.author Marzi S.
dc.contributor.author Romby P.
dc.contributor.author Yusupova G.
dc.contributor.author Yusupov M.
dc.contributor.author Hashem Y.
dc.date.accessioned 2018-09-19T20:31:19Z
dc.date.available 2018-09-19T20:31:19Z
dc.date.issued 2016
dc.identifier.issn 0305-1048
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/142979
dc.description.abstract © 2016 The Author(s).Comparative structural studies of ribosomes from various organisms keep offering exciting insights on how species-specific or environment-related structural features of ribosomes may impact translation specificity and its regulation. Although the importance of such features may be less obvious within more closely related organisms, their existence could account for vital yet species-specific mechanisms of translation regulation that would involve stalling, cell survival and antibiotic resistance. Here, we present the first full 70S ribosome structure from Staphylococcus aureus, a Gram-positive pathogenic bacterium, solved by cryo-electron microscopy. Comparative analysis with other known bacterial ribosomes pinpoints several unique features specific to S. aureus around a conserved core, at both the protein and the RNA levels. Our work provides the structural basis for the many studies aiming at understanding translation regulation in S. aureus and for designing drugs against this often multi-resistant pathogen.
dc.relation.ispartofseries Nucleic Acids Research
dc.title Structure of the 70S ribosome from human pathogen Staphylococcus aureus
dc.type Article
dc.relation.ispartofseries-issue 21
dc.relation.ispartofseries-volume 44
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 10491
dc.source.id SCOPUS03051048-2016-44-21-SID85016153148


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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