The action of bacillus' metzinc metalloproteinase on cultured animal cell lines

dc.contributor.author	Danilova J.
dc.contributor.author	Kirillova J.
dc.contributor.author	Rudakova N.
dc.contributor.author	Bogomolnaya L.
dc.contributor.author	Balaban N.
dc.contributor.author	Sharipova M.
dc.date.accessioned	2018-09-18T20:49:00Z
dc.date.available	2018-09-18T20:49:00Z
dc.date.issued	2014
dc.identifier.issn	2313-1829
dc.identifier.uri	https://dspace.kpfu.ru/xmlui/handle/net/142456
dc.description.abstract	Microbial enzymes with high activity are increasingly used in medical practice in development of drugs for treatment of burn injuries, diseases of gastrointestinal tract, as well as in systemic enzyme therapy. One of crucial requirements for such drugs is the absence of toxicity, both on cellular and organism levels. The aim of the present study was to evaluate cytotoxic effect of Bacillus pumilus metzinc metalloproteinase on animal cell lines. Cytological changes in LEK, Vero and PK-15 cell lines were observed after cell treatment with 155 μ/ml enzyme. However, lower enzyme concentrations - 75 and 15 μ/ml did not show any toxicity.
dc.relation.ispartofseries	Genes and Cells
dc.subject	Cultured cell lines
dc.subject	Cytotoxicity
dc.subject	Metzinc metalloproteinase
dc.subject	Viability
dc.title	The action of bacillus' metzinc metalloproteinase on cultured animal cell lines
dc.type	Article
dc.relation.ispartofseries-issue	1
dc.relation.ispartofseries-volume	9
dc.collection	Публикации сотрудников КФУ
dc.relation.startpage	72
dc.source.id	SCOPUS23131829-2014-9-1-SID84906907918

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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.