dc.contributor.author |
Lozhkin A. |
|
dc.contributor.author |
Biktagirov T. |
|
dc.contributor.author |
Abdul'yano V. |
|
dc.contributor.author |
Gorshkiv O. |
|
dc.contributor.author |
Timonina E. |
|
dc.contributor.author |
Mamin G. |
|
dc.contributor.author |
Orlinskii S. |
|
dc.contributor.author |
Silkin N. |
|
dc.contributor.author |
Chernov V. |
|
dc.contributor.author |
Khairullin R. |
|
dc.contributor.author |
Salakhov M. |
|
dc.contributor.author |
Ilinskaya O. |
|
dc.date.accessioned |
2018-09-18T20:48:59Z |
|
dc.date.available |
2018-09-18T20:48:59Z |
|
dc.date.issued |
2012 |
|
dc.identifier.issn |
2310-6905 |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/142453 |
|
dc.description.abstract |
The role of transition metal ions in atherogenesis is controversial; they can participate in the hydroxyl radical generation and catalyze the reactive oxygen species neutralization reaction as cofactors of antioxidant enzymes. Using EPR spectroscopy, we revealed that 70% of the samples of aorta with atherosclerotic lesions possessed superoxide dismutase activity, 100% of the samples initiated Fenton reaction and demonstrated the presence of manganese paramagnetic centers. The sodA gene encoding manganese-dependent bacterial superoxide dismutase was not found in the samples of atherosclerotic plaques by PCR using degenerate primers. The data obtained indicates the perspectives of manganese analysis as a marker element in the express diagnostics of atherosclerosis. |
|
dc.relation.ispartofseries |
Biomeditsinskaya Khimiya |
|
dc.subject |
Atherosclerosis |
|
dc.subject |
Manganese |
|
dc.subject |
SodA gene |
|
dc.subject |
Superoxide dismutase |
|
dc.title |
Manganese in atherogenesis: Detection, origin, and role |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
3 |
|
dc.relation.ispartofseries-volume |
58 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
291 |
|
dc.source.id |
SCOPUS23106905-2012-58-3-SID84864350210 |
|