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dc.contributor.author | Tsutsui A. | |
dc.contributor.author | Pradipta A. | |
dc.contributor.author | Saigitbatalova E. | |
dc.contributor.author | Kurbangalieva A. | |
dc.contributor.author | Tanaka K. | |
dc.date.accessioned | 2018-09-18T20:45:38Z | |
dc.date.available | 2018-09-18T20:45:38Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 2040-2503 | |
dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/142275 | |
dc.description.abstract | © 2015 The Royal Society of Chemistry. We synthetically demonstrate that eight-membered heterocycles, namely, 2,6,9-triazabicyclo[3.3.1]nonanes and 1,5-diazacyclooctanes, are the exclusive products of the reaction of acrolein with biologically relevant amines via an imino[4 + 4]cycloaddition. These compounds are produced in much higher amounts and efficiencies than the acrolein biomarker in current use, 3-formyl-3,4-dehydropiperidine (FDP). Our results not only indicate that eight-membered heterocycles may potentially be used as new biomarkers, but also strongly suggest the involvement of these heterocycles in various important biological phenomena, e.g., an acrolein-mediated mechanism underlying oxidative stress. | |
dc.relation.ispartofseries | MedChemComm | |
dc.title | Exclusive formation of imino[4 + 4]cycloaddition products with biologically relevant amines: Plausible candidates for acrolein biomarkers and biofunctional modulators | |
dc.type | Article | |
dc.relation.ispartofseries-issue | 3 | |
dc.relation.ispartofseries-volume | 6 | |
dc.collection | Публикации сотрудников КФУ | |
dc.relation.startpage | 431 | |
dc.source.id | SCOPUS20402503-2015-6-3-SID84924428149 |