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Enzyme-activated intracellular drug delivery with tubule clay nanoformulation

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dc.contributor.author Dzamukova M.
dc.contributor.author Naumenko E.
dc.contributor.author Lvov Y.
dc.contributor.author Fakhrullin R.
dc.date.accessioned 2018-09-18T20:36:45Z
dc.date.available 2018-09-18T20:36:45Z
dc.date.issued 2015
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/141684
dc.description.abstract Fabrication of stimuli-triggered drug delivery vehicle s is an important milestone in treating cancer. Here we demonstrate the selective anticancer drug delivery into human cells with biocompatible 50-nm diameter halloysite nanotube carriers. Physically-adsorbed dextrin end stoppers secure the intercellular release of brilliant green. Drug-loaded nanotubes penetrate through the cellular membranes and their uptake efficiency depends on the cells growth rate. Intercellular glycosyl hydrolases-mediated decomposition of the dextrin tube-end stoppers triggers the release of the lumen-loaded brilliant green, which allowed for preferable elimination of human lung carcinoma cells (Crossed D sign 549) as compared with hepatoma cells (Hep3b). The enzyme-activated intracellular delivery of brilliant green using dextrin-coated halloysite nanotubes is a promising platform for anticancer treatment.
dc.title Enzyme-activated intracellular drug delivery with tubule clay nanoformulation
dc.type Article
dc.relation.ispartofseries-volume 5
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS-2015-5-SID84929325979


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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