Показать сокращенную информацию
dc.contributor.author | Gerasimov A. | |
dc.contributor.author | Ziganshin M. | |
dc.contributor.author | Gorbatchuk V. | |
dc.contributor.author | Usmanova L. | |
dc.date.accessioned | 2018-09-18T20:36:09Z | |
dc.date.available | 2018-09-18T20:36:09Z | |
dc.date.issued | 2014 | |
dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/141585 | |
dc.description.abstract | Objective: The objective of the present study is a determination of optimal ratios of polyethylene glycol:sulfanilamide at which formation of solid dispersion is observed. Also study the effect of the polymer on the limiting solubility of sulfanilamide in water. Methods: Using low-temperature differential scanning calorimetry (DSC), it was made possible to obtain solid dispersions of sulfanilamide with polyethylene glycols having average molecular weight 1000 and 1400. UV-spectroscopy was used to determine the effect of polymer on limiting solubility of sulfanilamide. Results: An optimal polymer:sulfanilamide ratios are 7:1 and 4:1 for PEG-1000 and PEG-1400, respectively. Polymer in a drug composition allows for the increase the sulfanilamide content in water up to 3.0 times as compared with the solution of individual drug. Conclusion: These promising materials can be used for manufacture of drugs in various forms: capsular drugs, ointment and suppositories. | |
dc.subject | Differential scanning calorimetry | |
dc.subject | Polyethylene glycol | |
dc.subject | Solid dispersion | |
dc.subject | Sulfanilamide | |
dc.title | Low molecular weight polyethylene glycols as matrix to obtain solid dispersions of sulfanilamide | |
dc.type | Article | |
dc.relation.ispartofseries-issue | 6 | |
dc.relation.ispartofseries-volume | 6 | |
dc.collection | Публикации сотрудников КФУ | |
dc.relation.startpage | 372 | |
dc.source.id | SCOPUS-2014-6-6-SID84903893496 |