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Structure and catalytic activity of α-chymotrypsin in solutions of gemini surfactants

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dc.contributor.author Valiullina Y.
dc.contributor.author Ermakova E.
dc.contributor.author Faizullin D.
dc.contributor.author Mirgorodskaya A.
dc.contributor.author Zuev Y.
dc.date.accessioned 2018-09-18T20:17:40Z
dc.date.available 2018-09-18T20:17:40Z
dc.date.issued 2014
dc.identifier.issn 1066-5285
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/138399
dc.description.abstract The regulatory effect of gemini alkylammonium surfactants (GSurf) with the hexamethylene spacer varying in the length of alkyl radicals on the structure and catalytic activity of a-chymotrypsin was studied. A correlation between the activity of a-chymotrypsin and the length of the alkyl radical of GSurf was found. Gemini surfactants enhance the enzyme activity below the critical micelle concentration (CMC) and inhibit that above the CMC. The results of IR spectroscopy and the data on tryptophan fluorescence show that the interaction of GSurf with a-chymotrypsin induces changes in the protein structure differed in intensity. The most probable enzyme complexes with GSurf were characterized by the molecular docking method. © 2014 Springer Science+Business Media, Inc.
dc.relation.ispartofseries Russian Chemical Bulletin
dc.subject A-chymotrypsin
dc.subject Catalytic activity
dc.subject Complexes
dc.subject Gemini surfactants
dc.subject Structure
dc.title Structure and catalytic activity of α-chymotrypsin in solutions of gemini surfactants
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 63
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 273
dc.source.id SCOPUS10665285-2014-63-1-SID84906856865


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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