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Binase-like guanyl-preferring ribonucleases are new members of Bacillus PhoP regulon

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dc.contributor.author Ulyanova V.
dc.contributor.author Vershinina V.
dc.contributor.author Ilinskaya O.
dc.contributor.author Harwood C.
dc.date.accessioned 2018-09-18T20:11:08Z
dc.date.available 2018-09-18T20:11:08Z
dc.date.issued 2015
dc.identifier.issn 0944-5013
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/137362
dc.description.abstract © 2014 Elsevier GmbH. Extracellular low-molecular weight guanyl-preferring ribonucleases (LMW RNases) of Bacillus sp. comprise a group of hydrolytic enzymes that share highly similar structural and catalytic characteristics with barnase, a ribonuclease from Bacillus amyloliquefaciens, and binase, a ribonuclease from Bacillus intermedius. Although the physical-chemical and catalytic properties of Bacillus guanyl-preferring ribonucleases are very similar, there is considerably more variation in the environmental conditions that lead to the induction of the genes encoding these RNases. Based on structural differences of their genes the guanyl-preferring ribonucleases have been sub-divided into binase-like and barnase-like groups. Here we show the ability of the key regulator of phosphate deficiency response, PhoP, to direct the transcription of the binase-like RNases but not barnase-like RNases. These results, together with our demonstration that binase-like RNases are induced in response to phosphate starvation, allow us to categorise this group of ribonucleases as new members of Bacillus PhoP regulon. In contrast, the barnase-like ribonucleases are relatively insensitive to the phosphate concentration and the environmental conditions that are responsible for their induction, and the regulatory elements involved, are currently unknown.
dc.relation.ispartofseries Microbiological Research
dc.subject Bacillus
dc.subject Binase
dc.subject Extracellular ribonuclease
dc.subject Phosphate starvation
dc.subject Stress response
dc.title Binase-like guanyl-preferring ribonucleases are new members of Bacillus PhoP regulon
dc.type Article
dc.relation.ispartofseries-volume 170
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 131
dc.source.id SCOPUS09445013-2015-170-SID84930039582


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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