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Conjugation of succinic acid to non-ionogenic amphiphilic polymers modulates their interaction with cell plasma membrane and reduces cytotoxic activity

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dc.contributor.author Bondar O.
dc.contributor.author Sagitova A.
dc.contributor.author Badeev Y.
dc.contributor.author Shtyrlin Y.
dc.contributor.author Abdullin T.
dc.date.accessioned 2018-09-18T20:10:34Z
dc.date.available 2018-09-18T20:10:34Z
dc.date.issued 2013
dc.identifier.issn 0927-7765
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/137276
dc.description.abstract Pluronic block copolymers L61 and L121 were reacted with succinic anhydride to produce, respectively, their mono- and bisderivatives with succinic acid. The critical micelle concentration of Pluronics decreased after modification. The modification of Pluronic L61 promoted its association with the plasma membrane of human cells and increased membrane damage, while the membranotropic activity of modified Pluronic L121 reduced compared to the initial copolymer. Modified Pluronics interfered with the viability, apoptosis induction and metabolism of A549 cells and skin fibroblasts to a much lesser extent presumably due to the introduction of succinic acid residue inhibited intracellular penetration of copolymers. Modified Pluronic L121 promoted the cellular uptake of doxorubicin and rhodamine 123 in A549 cells attributed to the inhibition of membrane P-glycoprotein. Our study provides an approach to assessing the mechanism of interaction of amphiphilic polymers with living cells and demonstrates that Pluronic-succinic acid conjugates can be used as safe and efficient modulators of intracellular drug delivery. © 2013 Elsevier B.V.
dc.relation.ispartofseries Colloids and Surfaces B: Biointerfaces
dc.subject Amphiphilic polymers
dc.subject Bioconjugates
dc.subject Cellular interfaces
dc.subject Cytotoxic activity
dc.subject Drug delivery
dc.subject Succinic acid
dc.subject Transmembrane transport
dc.title Conjugation of succinic acid to non-ionogenic amphiphilic polymers modulates their interaction with cell plasma membrane and reduces cytotoxic activity
dc.type Article
dc.relation.ispartofseries-volume 109
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 204
dc.source.id SCOPUS09277765-2013-109-SID84877316673


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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