dc.contributor.author |
Zairov R. |
|
dc.contributor.author |
Khakimullina G. |
|
dc.contributor.author |
Podyachev S. |
|
dc.contributor.author |
Nizameev I. |
|
dc.contributor.author |
Safiullin G. |
|
dc.contributor.author |
Amirov R. |
|
dc.contributor.author |
Vomiero A. |
|
dc.contributor.author |
Mustafina A. |
|
dc.date.accessioned |
2018-04-05T07:10:22Z |
|
dc.date.available |
2018-04-05T07:10:22Z |
|
dc.date.issued |
2017 |
|
dc.identifier.uri |
http://dspace.kpfu.ru/xmlui/handle/net/130402 |
|
dc.description.abstract |
© 2017 The Author(s). Today, nanostructure-based contrast agents (CA) are emerging in the field of magnetic resonance imaging (MRI). Their sensitivity is reported as greatly improved in comparison to commercially used chelate-based ones. The present work is aimed at revealing the factors governing the efficiency of longitudinal magnetic relaxivity (r 1 ) in aqueous colloids of core-shell Gd(III)-based nanoparticles. We report for the first time on hyd ration number (q) of gadolinium(III) as a substantial factor in controlling r 1 values of polyelectrolyte-stabilized nanoparticles built from water insoluble complexes of Gd(III). The use of specific complex structure enables to reveal the impact of the inner-sphere hydration number on both r 1 values for the Gd(III)-based nanoparticles and the photophysical properties of their luminescent Tb(III) and Eu(III) counterparts. The low hydration of TTA-based Gd(III) complexes (q ≈ 1) agrees well with the poor relaxivity values (r 1 = 2.82 mM -1 s -1 and r 2 = 3.95 mM -1 s -1 ), while these values tend to increase substantially (r 1 = 12.41 mM -1 s -1 , r 2 = 14.36 mM -1 s -1 ) for aqueous Gd(III)-based colloids, when macrocyclic 1,3-diketonate is applied as the ligand (q ≈ 3). The regularities obtained in this work are fundamental in understanding the efficiency of MRI probes in the fast growing field of nanoparticulate contrast agents. |
|
dc.title |
Hydration number: Crucial role in nuclear magnetic relaxivity of Gd(III) chelate-based nanoparticles |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
1 |
|
dc.relation.ispartofseries-volume |
7 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.source.id |
SCOPUS-2017-7-1-SID85032283318 |
|