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Serum Cytokine Profile in a Patient Diagnosed with Dysferlinopathy

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dc.contributor.author Khaiboullina S.
dc.contributor.author Martynova E.
dc.contributor.author Bardakov S.
dc.contributor.author Mavlikeev M.
dc.contributor.author Yakovlev I.
dc.contributor.author Isaev A.
dc.contributor.author Deev R.
dc.contributor.author Rizvanov A.
dc.date.accessioned 2018-04-05T07:09:56Z
dc.date.available 2018-04-05T07:09:56Z
dc.date.issued 2017
dc.identifier.issn 1687-9627
dc.identifier.uri http://dspace.kpfu.ru/xmlui/handle/net/130077
dc.description.abstract © 2017 Svetlana F. Khaiboullina et al. Limb-girdle muscular dystrophy type 2 (LGMD2B) is a mild form of dysferlinopathy, characterized by limb weakness and wasting. It is an autosomal recessive disease, with currently 140 mutations in the LGMD2B gene identified. Lack of functional dysferlin inhibits muscle fiber regeneration in voluntary muscles, the main pathological finding in LGMD2B patients. However, the immune system has been suggested to contribute to muscle cell death and tissue regeneration. Serum levels of 27 cytokines wer e evaluated in a dysferlinopathy patient. Levels of 8 cytokines differed in patient serum compared to controls. Five cytokines (IL-10, IL-17, CCL2, CXCL10, and G-CSF) were higher while 3 were lower in the patient than in controls (IL-2, IL-8, and CCL11). Together, these data on serum cytokine profile of this dysferlinopathy patient suggest immune response activation, which could explain leukocyte infiltration in the muscle tissue.
dc.relation.ispartofseries Case Reports in Medicine
dc.title Serum Cytokine Profile in a Patient Diagnosed with Dysferlinopathy
dc.type Article
dc.relation.ispartofseries-volume 2017
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS16879627-2017-2017-SID85032647058


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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