Показать сокращенную информацию
dc.contributor.author | Brütting C. | |
dc.contributor.author | Kataeva O. | |
dc.contributor.author | Schmidt A. | |
dc.contributor.author | Knölker H. | |
dc.date.accessioned | 2018-04-05T07:09:51Z | |
dc.date.available | 2018-04-05T07:09:51Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1434-193X | |
dc.identifier.uri | http://dspace.kpfu.ru/xmlui/handle/net/130014 | |
dc.description.abstract | © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim We describe the first total synthesis of the cytotoxic carbazole alkaloid excavatine-A. The carbazole framework was constructed through double C–H bond activation of a diarylamine by using our palladium(II)-catalyzed oxidative cyclization. Treatment of the intermediate 8-hydroxycarbazoles with prenal and different additives led either to pyrano[2,3-a]carbazoles or to [1,4] oxazepino[2,3,4-jk]carbazoles. The pyran annulation was investigated to determine the influence of substitution pattern, additives, and reaction time on the selectivity. | |
dc.relation.ispartofseries | European Journal of Organic Chemistry | |
dc.subject | Alkaloids | |
dc.subject | Carbazoles | |
dc.subject | Oxazepines | |
dc.subject | Palladium | |
dc.subject | Total synthesis | |
dc.title | First Total Synthesis of the Cytotoxic Carbazole Alkaloid Excavatine-A and Regioselective Annulation to Pyrano[2,3-a]carbazoles and [1,4]Oxazepino[2,3,4-jk]carbazoles | |
dc.type | Article | |
dc.relation.ispartofseries-issue | 22 | |
dc.relation.ispartofseries-volume | 2017 | |
dc.collection | Публикации сотрудников КФУ | |
dc.relation.startpage | 3288 | |
dc.source.id | SCOPUS1434193X-2017-2017-22-SID85020530327 |