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dc.contributor.author | Tsepaeva O. | |
dc.contributor.author | Nemtarev A. | |
dc.contributor.author | Abdullin T. | |
dc.contributor.author | Grigor'Eva L. | |
dc.contributor.author | Kuznetsova E. | |
dc.contributor.author | Akhmadishina R. | |
dc.contributor.author | Ziganshina L. | |
dc.contributor.author | Cong H. | |
dc.contributor.author | Mironov V. | |
dc.date.accessioned | 2018-04-05T07:09:14Z | |
dc.date.available | 2018-04-05T07:09:14Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0163-3864 | |
dc.identifier.uri | http://dspace.kpfu.ru/xmlui/handle/net/129597 | |
dc.description.abstract | © 2017 The American Chemical Society and American Society of Pharmacognosy. A series of new triphenylphosphonium (TPP) derivatives of the triterpenoid betulin (1, 3-lup-20(29)-ene-3β,28-diol) have been synthesized and evaluated for cytotoxic effects against human breast cancer (MCF-7), prostate adenocarcinoma (PC-3), vinblastine-resistant human breast cancer (MCF-7/Vinb), and human skin fibroblast (HSF) cells. The TPP moiety was applied as a carrier group through the acyl linker at the 28- or 3- and 28-positions of betulin to promote cellular and mitochondrial accumulation of the resultant compounds. A structure-activity relationship study has revealed the essential role of the TPP group in the biological properties of the betulin derivatives produced. The present results showed that a conjugate of betulin with TPP (3) enhanced antiproliferative activity toward vinblastine-resistant MCF-7 cells, with an IC 50 value as low as 0.045 μM. | |
dc.relation.ispartofseries | Journal of Natural Products | |
dc.title | Design, Synthesis, and Cancer Cell Growth Inhibitory Activity of Triphenylphosphonium Derivatives of the Triterpenoid Betulin | |
dc.type | Article | |
dc.relation.ispartofseries-issue | 8 | |
dc.relation.ispartofseries-volume | 80 | |
dc.collection | Публикации сотрудников КФУ | |
dc.relation.startpage | 2232 | |
dc.source.id | SCOPUS01633864-2017-80-8-SID85028342968 |