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Hemocoagulation Activity of Sulfur-Containing Pinane-Type Terpenoids

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dc.contributor.author Kiselev S.
dc.contributor.author Nikitina L.
dc.contributor.author Startseva V.
dc.contributor.author Artemova N.
dc.contributor.author Bodrov A.
dc.contributor.author Boichuk S.
dc.contributor.author Vorontsova M.
dc.contributor.author Rakhmatullina A.
dc.contributor.author Turaev R.
dc.contributor.author Klochkov V.
dc.date.accessioned 2018-04-05T07:09:13Z
dc.date.available 2018-04-05T07:09:13Z
dc.date.issued 2017
dc.identifier.issn 0091-150X
dc.identifier.uri http://dspace.kpfu.ru/xmlui/handle/net/129584
dc.description.abstract © 2017, Springer Science+Business Media, LLC. A series of pinane-type sulfides and sulfoxides were synthesized from (1S)-(–)-β-pinene. Their hemocoagulation activity in vitro on human blood plasma was studied. All tested compounds exhibited antiaggregation and anticoagulation activity. The most water-soluble sulfoxide with a mercaptoacetic acid moiety inhibited spontaneous platelet aggregation and that induced by collagen and arachidonic acid and also reduced the coagulation activity of human blood plasma. The hemocoagulation activity was due to selective inhibition of platelet receptors, decreased yield of thrombocytic microvesicles, and suppression of their activity.
dc.relation.ispartofseries Pharmaceutical Chemistry Journal
dc.subject (1S)-(–)-β-pinene
dc.subject antiaggregation and anticoagulation activity
dc.subject platelets
dc.subject sulfides and sulfoxides
dc.title Hemocoagulation Activity of Sulfur-Containing Pinane-Type Terpenoids
dc.type Article
dc.relation.ispartofseries-issue 5
dc.relation.ispartofseries-volume 51
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 343
dc.source.id SCOPUS0091150X-2017-51-5-SID85029155775


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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