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dc.contributor | Казанский федеральный университет | |
dc.contributor.author | Yakovleva Olga Vladislavovna | |
dc.contributor.author | Burhanova Gulshat Foatovna | |
dc.contributor.author | Gerasimova Elena Vyacheslavovna | |
dc.contributor.author | Ziyatdinova Guzel Kamilevna | |
dc.contributor.author | Sitdikova Guzel Faritovna | |
dc.contributor.author | Haertdinov Nail Nazimovich | |
dc.date.accessioned | 2016-10-20T12:29:33Z | |
dc.date.available | 2016-10-20T12:29:33Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Gerasimova Е. Effects of Maternal Hyperhomocysteinemia on the Early Physical Development and Neurobehavioral Maturation of Rat Offspring / E. Gerasimova, O. Yakovleva, G. Burkhanova, G. Ziyatdinova, N. Khaertdinov, G. Sitdikova // BioNanoScience. - 2016. | |
dc.identifier.uri | http://dspace.kpfu.ru/xmlui/handle/net/105897 | |
dc.description.abstract | During pregnancy, several complications have been associated with hyperhomocysteinemia and elevated homocysteine (Hcy) levels have been shown to play a role in the etiology of preeclampsia, placental abruption, intrauterine growth retardation, and neural tube defects. In the present work we aimed to investigate the effects of maternal Hcy on the development and neurobehavioral maturation of the offspring. On the pups, we performed a follow-up of classical parameters of development such as body weight, eyelid opening, ear unfolding, incisor eruption and the appearance of hair, and subjected the pups to various tests representative of neurobehavioral maturation extending from 4th to 20th postnatal days (righting reflex, negative geotaxis, cliff avoidance, head shake, acoustic startle reflex, free-fall righting, cliff avoidance caused by visual stimulus, olfactory discrimination). We have shown that newborn animals were characterized by lower body weight and higher mortality. | |
dc.language.iso | en | |
dc.relation.ispartofseries | BioNanoScience | |
dc.rights | открытый доступ | |
dc.subject | Keywords maternal hyperhomocysteinemia | |
dc.subject | neonatal development | |
dc.subject | rat | |
dc.subject | neurobehavioral maturation | |
dc.subject.other | Биология | |
dc.title | Effects of Maternal Hyperhomocysteinemia on the Early Physical Development and Neurobehavioral Maturation of Rat Offspring | |
dc.type | Article | |
dc.contributor.org | Институт фундаментальной медицины и биологии | |
dc.description.pages | ||
dc.pub-id | 141509 |