Browsing by Author "Welsh G."

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A systems model of phosphorylation for inflammatory signaling events

Sadreev I.; Chen M.; Welsh G.; Umezawa Y.; Kotov N.; Valeyev N. (2014)

© 2014 Sadreev et al. Phosphorylation is a fundamental biochemical reaction that modulates protein activity in cells. While a single phosphorylation event is relatively easy to understand, multisite phosphorylation requires ...
Kinetic regulation of multi-ligand binding proteins

Salakhieva D.; Sadreev I.; Chen M.; Umezawa Y.; Evstifeev A.; Welsh G.; Kotov N. (2016)

© 2016 Salakhieva et al.Background: Second messengers, such as calcium, regulate the activity of multisite binding proteins in a concentration-dependent manner. For example, calcium binding has been shown to induce ...
The competitive nature of signal transducer and activator of transcription complex formation drives phenotype switching of T cells

Sadreev I.; Chen M.; Umezawa Y.; Biktashev V.; Kemper C.; Salakhieva D.; Welsh G.; Kotov N. (2017)

© 2017 John Wiley & Sons Ltd. Signal transducers and activators of transcription (STATs) are key molecular determinants of T-cell fate and effector function. Several inflammatory diseases are characterized by an altered ...

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