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Browsing by Author "Weisel J."

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Activated Monocytes Enhance Platelet-Driven Contraction of Blood Clots via Tissue Factor Expression

Peshkova A.; Le Minh G.; Tutwiler V.; Andrianova I.; Weisel J.; Litvinov R. (2017)

© 2017 The Author(s). Platelet-driven reduction in blood clot volume (clot contraction or retraction) has been implicated to play a role in hemostasis and thrombosis. Although these processes are often linked with inflammation, ...
Age-Dependent Differential Staining of Fibrin in Blood Clots and Thrombi

Khismatullin R.; Shakirova A.; Weisel J.; Litvinov R. (2019)

© 2019, Springer Science+Business Media, LLC, part of Springer Nature. It has been known for a long time that histologically fibrin can be visualized as a fibrous structure of variable colors, even when stained with the ...
Atomic Structural Models of Fibrin Oligomers

Zhmurov A.; Protopopova A.; Litvinov R.; Zhukov P.; Weisel J.; Barsegov V. (2018)

© 2018 Elsevier Ltd The space-filling fibrin network is a major part of clots and thrombi formed in blood. Fibrin polymerization starts when fibrinogen, a plasma protein, is proteolytically converted to fibrin, which ...
Blood clot contraction differentially modulates internal and external fibrinolysis

Tutwiler V.; Peshkova A.; Le Minh G.; Zaitsev S.; Litvinov R.; Cines D.; Weisel J. (2019)

© 2018 International Society on Thrombosis and Haemostasis Essentials Clot contraction influences the rate of fibrinolysis in vitro. Internal fibrinolysis is enhanced ∼2-fold in contracted vs. uncontracted blood clots. ...
Circulating Microparticles Alter Formation, Structure, and Properties of Fibrin Clots

Zubairova L.; Nabiullina R.; Nagaswami C.; Zuev Y.; Mustafin I.; Litvinov R.; Weisel J. (2015)

Despite the importance of circulating microparticles in haemostasis and thrombosis, there is limited evidence for potential causative effects of naturally produced cell-derived microparticles on fibrin clot formation and ...
Conformational Flexibility and Self-Association of Fibrinogen in Concentrated Solutions

Zuev Y.; Litvinov R.; Sitnitsky A.; Idiyatullin B.; Bakirova D.; Galanakis D.; Zhmurov A.; Barsegov V.; Weisel J. (2017)

© 2017 American Chemical Society. We studied the hydrodynamic behavior of fibrinogen, a blood plasma protein involved in blood clotting, in a broad 0.3-60 mg/mL range of concentration and 5-42 °C temperature using pulsed-field ...
Contraction of blood clots is impaired in acute ischemic stroke

Tutwiler V.; Peshkova A.; Andrianova I.; Khasanova D.; Weisel J.; Litvinov R. (2017)

© 2016 American Heart Association, Inc.Objective - Obstructive thrombi or thrombotic emboli are the pathogenic basis of ischemic stroke. In vitro blood clots and in vivo thrombi can undergo platelet-driven contraction ...
Contribution of nascent cohesive fiber-fiber interactions to the non-linear elasticity of fibrin networks under tensile load

Britton S.; Kim O.; Pancaldi F.; Xu Z.; Litvinov R.; Weisel J.; Alber M. (2019)

© 2019 Acta Materialia Inc. Fibrin is a viscoelastic proteinaceous polymer that determines the deformability and integrity of blood clots and fibrin-based biomaterials in response to biomechanical forces. Here, a previously ...
Differential Sensitivity of Various Markers of Platelet Activation with Adenosine Diphosphate

Le Minh G.; Peshkova A.; Andrianova I.; Weisel J.; Litvinov R. (2019)

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. A number of techniques have been available to assess platelet activation, but their relative sensitivity is unknown and their usage is variable and not ...
Factor XIII topology: organization of B subunits and changes with activation studied with single-molecule atomic force microscopy

Protopopova A.; Ramirez A.; Klinov D.; Litvinov R.; Weisel J. (2019)

© 2019 International Society on Thrombosis and Haemostasis Essentials Factor XIII is a heterotetramer with 2 catalytic A subunits and 2 non-catalytic B subunits. Structure of active and inactive factor XIII was studied ...
Fatal dysfunction and disintegration of thrombin-stimulated platelets

Kim O.; Nevzorova T.; Mordakhanova E.; Ponomareva A.; Andrianova I.; Minh G.; Daminova A.; Peshkova A.; Alber M.; Vagin O.; Litvinov R.; Weisel J. (2019)

© 2019 Ferrata Storti Foundation. Platelets play a key role in the formation of hemostatic clots and obstructive thrombi as well as in other biological processes. In response to physiological stimulants, including thrombin, ...
In systemic lupus erythematosus anti-dsDNA antibodies can promote thrombosis through direct platelet activation

Andrianova I.; Ponomareva A.; Mordakhanova E.; Le Minh G.; Daminova A.; Nevzorova T.; Rauova L.; Litvinov R.; Weisel J. (2019)

© 2019 Elsevier Ltd Systemic lupus erythematosus (SLE) is associated with a high risk of venous and arterial thrombosis, not necessarily associated with prothrombotic antiphospholipid antibodies (Abs). Alternatively, ...
Intracellular origin and ultrastructure of platelet-derived microparticles

Ponomareva A.; Nevzorova T.; Mordakhanova E.; Andrianova I.; Rauova L.; Litvinov R.; Weisel J. (2017)

© 2017 International Society on Thrombosis and Haemostasis Essentials Platelet microparticles play a major role in pathologies, including hemostasis and thrombosis. Platelet microparticles have been analyzed and classified ...
Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood

Tutwiler V.; Litvinov R.; Lozhkin A.; Peshkova A.; Lebedeva T.; Ataullakhanov F.; Spiller K.; Cines D.; Weisel J. (2016)

© 2016 by The American Society of Hematology. Platelet-driven blood clot contraction (retraction) is thought to promote wound closure and secure hemostasis while preventing vascular occlusion. Notwithstanding its importance, ...
Lytic susceptibility, structure, and mechanical properties of fibrin in systemic lupus erythematosus

Litvinov R.; Nabiullina R.; Zubairova L.; Shakurova M.; Andrianova I.; Weisel J. (2019)

Copyright © 2019 Litvinov, Nabiullina, Zubairova, Shakurova, Andrianova and Weisel. Among complications of systemic lupus erythematosus (SLE), thrombotic events are relatively common and contribute significantly to the ...
Mechanistic Basis for the Binding of RGD- and AGDV-Peptides to the Platelet Integrin αIIbβ3

Kononova O.; Litvinov R.; Blokhin D.; Klochkov V.; Weisel J.; Bennett J.; Barsegov V. (2017)

© 2017 American Chemical Society.Binding of soluble fibrinogen to the activated conformation of the integrin αIIbβ3 is required for platelet aggregation and is mediated exclusively by the C-terminal AGDV-containing ...
Model predictions of deformation, embolization and permeability of partially obstructive blood clots under variable shear flow

Xu S.; Xu Z.; Kim O.; Litvinov R.; Weisel J.; Alber M. (2017)

© 2017 The Author(s) Published by the Royal Society. All rights reserved. Thromboembolism, one of the leading causes of morbidity and mortality worldwide, is characterized by formation of obstructive intravascular clots ...
Morphometric characterization of fibrinogen's αc regions and their role in fibrin self-assembly and molecular organization

Protopopova A.; Litvinov R.; Galanakis D.; Nagaswami C.; Barinov N.; Mukhitov A.; Klinov D.; Weisel J. (2017)

© 2017 The Royal Society of Chemistry. The flexible C-terminal parts of fibrinogen's Aα chains named the αC regions have been shown to play a role in fibrin self-assembly, although many aspects of their structure and ...
Neutrophil a-defensins promote thrombosis in vivo by altering fibrin formation, structure, and stability

Abu-Fanne R.; Stepanova V.; Litvinov R.; Abdeen S.; Bdeir K.; Higazi M.; Maraga E.; Nagaswami C.; Mukhitov A.; Weisel J.; Cines D.; Higazi A. (2019)

© 2019 by The American Society of Hematology. Inflammation and thrombosis are integrated, mutually reinforcing processes, but the interregulatory mechanisms are incompletely defined. Here, we examined the contribution of ...
Platelet factor 4-containing immune complexes induce platelet activation followed by calpain-dependent platelet death

Nevzorova T.; Mordakhanova E.; Daminova A.; Ponomareva A.; Andrianova I.; Le Minh G.; Rauova L.; Litvinov R.; Weisel J. (2019)

© 2019, The Author(s). Heparin-induced thrombocytopenia (HIT) is a complication of heparin therapy sometimes associated with thrombosis. The hallmark of HIT is antibodies to the heparin/platelet factor 4 (PF4) complex that ...

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Browsing by Author "Weisel J."

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