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Browsing by Author "Ulyanova V."

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A Novel Antiviral Strategy against MERS-CoV and HCoV-229E Using Binase to Target Viral Genome Replication

Müller C.; Ulyanova V.; Ilinskaya O.; Pleschka S.; Shah Mahmud R. (2017)

© 2016, Springer Science+Business Media New York.RNA viruses cause most of the dangerous communicable diseases. Due to their high mutation rates, RNA viruses quickly evade selective pressures and can adapt to a new host. ...
A Set of Genetic Constructs for Binase and Barstar Overproduction

Ulyanova V.; Shah Mahmud R.; Klug G.; Preissner K.; Vershinina V.; Ilinskaya O. (2017)

© 2016, Springer Science+Business Media New York.Low molecular weight guanyl-preferring ribonuclease (RNase) secreted by Bacillus pumilus is referred to as binase and regarded as a potential agent to target oncogenic ...
Anti-influenza activity of the ribonuclease binase: Cellular targets detected by quantitative proteomics

Ulyanova V.; Mahmud R.S.; Laikov A.; Dudkina E.; Markelova M.; Mostafa A.; Pleschka S.; Ilinskaya O. (2020)

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Unpredictable influenza pandemics, annual epidemics, and sporadic poultry-to-human avian influenza virus infections with high morbidity and mortality rates dictate ...
Antiviral Activity of Bacterial Extracellular Ribonuclease Against Single-, Double-Stranded RNA and DNA Containing Viruses in Cell Cultures

Shah Mahmud R.; Efimova M.; Mostafa A.; Ulyanova V.; Ilinskaya O. (2016)

© 2016, Springer Science+Business Media New York.Binase, a small guanyl-preferring extracellular ribonuclease of Gram-positive non-pathogenic soil bacteria Bacillus pumilus. Binase is a well-known bacterial ribonuclease, ...
Bacillus pumilus ribonuclease rescues mice infected by double-stranded RNA-containing reovirus serotype 1

Shah Mahmud R.; Efimova M.A.; Ulyanova V.; Ravilov R.K.; Shuralev E.A.; Kolpakov A.; Ilinskaya O. (2020)

© 2020 Elsevier B.V. Reoviruses (respiratory enteric orphan viruses) are nonenveloped viruses with segmented dsRNA genome. Viruses in the family Reoviridae are quite stable in the environment. Recently, they have been ...
Bacteriophages of soil bacilli: A new multivalent phage of Bacillus altitudinis

Shah Mahmud R.; Garifulina K.; Ulyanova V.; Evtugyn V.; Mindubaeva L.; Khazieva L.; Dudkina E.; Vershinina V.; Kolpakov A.; Ilinskaya O. (2017)

© 2017, Allerton Press, Inc. Bacillus are soil saprophytes, facultative anaerobes developing in the temperature range of 28–37°С. 16S rRNA cataloging shows that these bacteria form a coherent class with broad variability ...
Balnase, a New Dimer-Forming Ribonuclease from Bacillus altitudinis

Dudkina E.; Ulyanova V.; Ilinskaya O. (2017)

© 2016, Springer Science+Business Media New York.Current cancer treatments still remain ineffective and cause side effects which ruinously affect healthy cells. Among new promising anticancer drugs, special attention is ...
Barnase and binase: Twins with distinct fates

Ulyanova V.; Vershinina V.; Ilinskaya O. (2011)

RNases are enzymes that cleave RNAs, resulting in remarkably diverse biological consequences. Many RNases are cytotoxic. In some cases, they attack selectively malignant cells triggering an apoptotic response. A number of ...
Binase Immobilized on halloysite nanotubes exerts enhanced cytotoxicity toward human colon adenocarcinoma cells

Khodzhaeva V.; Makeeva A.; Ulyanova V.; Zelenikhin P.; Evtugyn V.; Hardt M.; Rozhina E.; Lvov Y.; Fakhrullin R.; Ilinskaya O. (2017)

© 2017 Khodzhaeva, Makeeva, Ulyanova. Many ribonucleases (RNases) are considered as promising tools for antitumor therapy because of their selective cytotoxicity toward cancer cells. Binase, the RNase from Bacillus pumilus, ...
Binase-like guanyl-preferring ribonucleases are new members of Bacillus PhoP regulon

Ulyanova V.; Vershinina V.; Ilinskaya O.; Harwood C. (2015)

Copyright © 2014 Elsevier GmbH. All rights reserved. Extracellular low-molecular weight guanyl-preferring ribonucleases (LMW RNases) of Bacillus sp. comprise a group of hydrolytic enzymes that share highly similar structural ...
Binase-like guanyl-preferring ribonucleases are new members of Bacillus PhoP regulon

Ulyanova V.; Vershinina V.; Ilinskaya O.; Harwood C. (2015)

© 2014 Elsevier GmbH. Extracellular low-molecular weight guanyl-preferring ribonucleases (LMW RNases) of Bacillus sp. comprise a group of hydrolytic enzymes that share highly similar structural and catalytic characteristics ...
Direct inhibition of oncogenic KRAS by Bacillus pumilus ribonuclease (binase)

Ilinskaya O.; Singh I.; Dudkina E.; Ulyanova V.; Kayumov A.; Barreto G. (2016)

© 2016 Elsevier B.V.RAS proteins function as molecular switches that transmit signals from cell surface receptors into specific cellular responses via activation of defined signaling pathways (Fang, 2015). Aberrant ...
Extracellular ribonuclease from bacillus licheniformis (Balifase), a New member of the N1/T1 RNase superfamily

Sokurenko Y.; Nadyrova A.; Ulyanova V.; Ilinskaya O. (2016)

© 2016 Yulia Sokurenko et al.The N1/T1 RNase superfamily comprises enzymes with well-established antitumor effects, such as ribotoxins secreted by fungi, primarily by Aspergillus and Penicillium species, and bacterial RNase ...
Identification of 2′,3′-cGMP as an intermediate of RNA catalytic cleavage by binase and evaluation of its biological action

Sokurenko Y.; Zelenikhin P.; Ulyanova V.; Kolpakov A.; Muller D.; Ilinskaya O. (2015)

© 2015 Pleiades Publishing, Ltd. Binase, the RNAse from Bacillus pumilus, is an endonuclease that cleaves the phosphodiester bond between the 3′-guanyl residue and 5′-OH residue of an adjacent nucleotide, with the formation ...
Improving Bacillus Altitudinis B-388 Genome Scaffolding Using Mate-Pair Next-Generation Sequencing

Ulyanova V.; Shah Mahmud R.; Malanin S.; Vershinina V.; Ilinskaya O. (2017)

© 2016, Springer Science+Business Media New York.Bacillus species, generally regarded as soil microorganisms, are present in human gastrointestinal tract (GIT) in quantities, which cannot be explained by their entrance ...
Phylogenetic distribution of extracellular guanyl-preferring ribonucleases renews taxonomic status of two bacillus strains

Ulyanova V.; Mahmud R.; Dudkina E.; Vershinina V.; Domann E.; Ilinskaya O. (2016)

© 2016 Applied Microbiology, Molecular and Cellular Biosciences Research Foundation.The potential of microbial ribonucleases as promising antitumor and antiviral agents, determines today’s directions of their study. One ...
Preparations of Bacillus pumilus secreted RNase: One enzyme or two?

Ulyanova V.; Khodzhaeva V.; Dudkina E.; Laikov A.; Vershinina V.; Ilinskaya O. (2015)

© 2015, Pleiades Publishing, Ltd. Immunochemical analysis of the following purified preparations of Bacillus pumilus RNase (binase) was carried out: industrially manufactured enzyme (Institute of Organic Synthesis, Riga, ...
Ribonuclease from bacillus acts as an antiviral agent against negative- and positive-sense single stranded human respiratory RNA viruses

Shah Mahmud R.; Müller C.; Romanova Y.; Mostafa A.; Ulyanova V.; Pleschka S.; Ilinskaya O. (2017)

Copyright © 2017 Raihan Shah Mahmud et al.Bacillus pumilus ribonuclease (binase) was shown to be a promising antiviral agent in animal models and cell cultures. However, the mode of its antiviral action remains unknown. ...
Role of a two-component ResD-ResE system in regulating the expression of guanyl-specific ribonuclease genes in Bacilli

Ulyanova V.; Zolotova M.; Kharitonova M.; Ilyinskaya O.; Vershinina V. (2008)

The role of the two-component ResD-ResE signal transduction system in regulating the expression of guanyl-specific ribonuclease genes in bacilli has been studied. Proteins with homologies to the ResD and ResE regulatory ...
Secretome of Intestinal bacilli: A natural guard against pathologies

Ilinskaya O.; Ulyanova V.; Yarullina D.; Gataullin I. (2017)

© 2017 Ilinskaya, Ulyanova, Yarullina and Gataullin. Current studies of human gut microbiome usually do not consider the special functional role of transient microbiota, although some of its members remain in the host for ...

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Browsing by Author "Ulyanova V."

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