Browsing by Subject "QM/MM"

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Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad

Grigorenko B.; Novichkova D.; Lushchekina S.; Zueva I.; Schopfer L.; Nemukhin A.; Varfolomeev S.; Lockridge O.; Masson P. (2019)

© 2019 Elsevier B.V. A computer-designed mutant of human butyrylcholinesterase (BChE), N322E/E325G, with a novel catalytic triad was made. The catalytic triad of the wild-type enzyme (S198·H438·E325) was replaced by ...
Steady-state kinetics of enzyme-catalyzed hydrolysis of echothiophate, a P–S bonded organophosphorus as monitored by spectrofluorimetry

Zueva I.V.; Lushchekina S.V.; Daudé D.; Chabrière E.; Masson P. (2020)

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/ ...

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