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Просмотр по теме "Pyridoxine"

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Antibacterial effects of quaternary bis-phosphonium and ammonium salts of pyridoxine on Staphylococcus aureus cells: A single base hitting two distinct targets?

Nikitina E.; Zeldi M.; Pugachev M.; Sapozhnikov S.; Shtyrlin N.; Kuznetsova S.; Evtygin V.; Bogachev M.; Kayumov A.; Shtyrlin Y. (2016)

© 2015, Springer Science+Business Media Dordrecht. We studied the effects of quaternary bis-phosphonium and bis-ammonium salts of pyridoxine with lipophilic substituents on the survival and morphology of Staphylococcus ...
Antibacterial effects of quaternary bis-phosphonium and ammonium salts of pyridoxine on Staphylococcus aureus cells: A single base hitting two distinct targets?

Nikitina E.; Zeldi M.; Pugachev M.; Sapozhnikov S.; Shtyrlin N.; Kuznetsova S.; Evtygin V.; Bogachev M.; Kayumov A.; Shtyrlin Y. (2016)

We studied the effects of quaternary bis-phosphonium and bis-ammonium salts of pyridoxine with lipophilic substituents on the survival and morphology of Staphylococcus aureus cells. We found that, while originating from ...
Bis-phosphonium salts of pyridoxine: The relationship between structure and antibacterial activity

Pugachev M.; Shtyrlin N.; Sapozhnikov S.; Sysoeva L.; Iksanova A.; Nikitina E.; Musin R.; Lodochnikova O.; Berdnikov E.; Shtyrlin Y. (2013)

A series of 23 novel bis-phosphonium salts based on pyridoxine were synthesized and their antibacterial activities were evaluated in vitro. All compounds were inactive against gram-negative bacteria and exhibited the ...
Complicated Conformational Exchange of New Pyridoxine Derivative. Dynamic<sup>13</sup>C NMR Characterization

Rakhmatullin I.; Galiullina L.; Karataeva F.; Klochkov V. (2017)

© 2017, Springer Science+Business Media, LLC. New pyridoxine derivative with multiple chemical exchanges was studied by 13 C (at 298 K, 188 K) and 2D NMR ( 1 H- 13 C HSQC, 1 H- 13 C HMBC) spectroscopy in acetone-d 6 solution. ...
Design, synthesis, antibacterial activity and toxicity of novel quaternary ammonium compounds based on pyridoxine and fatty acids

Sapozhnikov S.V.; Sabirova A.E.; Shtyrlin N.V.; Druk A.Y.; Agafonova M.N.; Chirkova M.N.; Kazakova R.R.; Grishaev D.Y.; Nikishova T.V.; Krylova E.S.; Nikitina E.V.; Kayumov A.R.; Shtyrlin Y.G. (2021)

A diverse series of 43 novel “soft antimicrobials” based on quaternary ammonium pyridoxine derivatives which include six-membered acetals and ketals of pyridoxine bound via cleavable linker moieties (amide, ester) with a ...
Dynamic NMR study of cyclic derivatives of pyridoxine

Rakhmatullin I.; Galiullina L.; Garipov M.; Strel'nik A.; Shtyrlin Y.; Klochkov V. (2014)

A series of pyridoxine derivatives was investigated by 1H and 2D nuclear overhauser enhancement spectroscopy (NOESY) NMR. The free energies of activation for the pyridyl-oxygen rotation of the 2,4-dinitrophenyl ether of ...
Isonicotinoyl hydrazones of pyridoxine derivatives: synthesis and antimycobacterial activity

Shtyrlin N.V.; Khaziev R.M.; Shtyrlin V.G.; Gilyazetdinov E.M.; Agafonova M.N.; Usachev K.S.; Islamov D.R.; Klimovitskii A.E.; Vinogradova T.I.; Dogonadze M.Z.; Zabolotnykh N.V.; Sokolovich E.G.; Yablonskiy P.K.; Shtyrlin Y.G. (2021)

A series of novel isonicotinoyl hydrazones based on pyridoxine (vitamin B6) were synthesized. The synthesized compounds were evaluated for their antimycobacterial activity on M. tuberculosis H37Rv strain. The most potent ...
New quaternary ammonium pyridoxine derivatives: synthesis and antibacterial activity

Sapozhnikov S.; Shtyrlin N.; Kayumov A.; Zamaldinova A.; Iksanova A.; Nikitina Е.; Krylova Е.; Grishaev D.; Balakin K.; Shtyrlin Y. (2017)

© 2017, Springer Science+Business Media, LLC. A diverse library of 34 new quaternary mono-ammonium and bis-ammonium pyridoxine derivatives was synthesized, and their antibacterial activity against several clinically relevant ...
Novel approach to 6-alkenyl-substituted pyridoxine derivatives based on the Heck reaction

Bulatov T.; Pugachev M.; Shtyrlin N.; Shtyrlin Y. (2018)

© 2018 Elsevier Ltd A new synthetic approach to 6-alkenyl-substituted pyridoxine derivatives was developed based on the Heck reaction. The reaction, which was catalyzed using a mixture of Pd(OAc)2, (o-Tol)3P and Bu3N as a ...
Novel bis-ammonium salts of pyridoxine: Synthesis and antimicrobial properties

Shtyrlin N.V.; Pugachev M.V.; Sapozhnikov S.V.; Garipov M.R.; Vafina R.M.; Grishaev D.Y.; Pavelyev R.S.; Kazakova R.R.; Agafonova M.N.; Iksanova A.G.; Lisovskaya S.A.; Zeldi M.I.; Krylova E.S.; Nikitina E.V.; Sabirova A.E.; Kayumov A.R.; Shtyrlin Y.G. (2020)

© 2020 by the authors. A series of 108 novel quaternary bis-ammonium pyridoxine derivatives carrying various substituents at the quaternary nitrogen’s and acetal carbon was synthesized. Thirteen compounds exhibited ...
Pyridoxonium salts of chiral and cyclic dithiophosphoric and bisdithiophosphonic acids and their antimicrobial activities

Nizamov I.S.; Belov T.G.; Nizamov I.D.; Nikitin Y.N.; Akhmedova G.R.; Shilnikova O.V.; Timushev I.D.; Salikhov R.Z.; Shulaeva M.P.; Pozdeev O.K.; Batyeva E.S.; Cherkasov R.A. (2020)

© 2020 Taylor & Francis Group, LLC. Pyridoxonium salts of chiral linear and cyclic dithiophosphoric acids were obtained by the reactions of pyridoxine with bis{2-О-[2-methyl-(2S)-3-O-propionyl]}, bis{2-О-[1,4-О,О-dimet ...
Spatial Structure and Conformational Mobility of Seven-Membered Cyclic Acetals and Ketals Containing Pyridoxine Moiety in Solution by NMR Methods

Rakhmatullin I.; Galiullina L.; Balandina A.; Karataeva F.; Shtyrlin Y.; Klochkov V. (2018)

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. In the last decade, pyridoxine derivatives were widely used for the synthesis of molecules with important biological and physical properties. However, ...
Stereodynamics of some pyridoxine derivatives

Rakhmatullin I.; Galiullina L.; Balandina A.; Garipov M.; Strelnik A.; Galiullina A.; Shtyrlin Y.; Klochkov V. (2016)

© 2016 John Wiley & Sons, Ltd.The conformational properties of three pyridoxine derivatives were studied by 1H dynamic NMR spectroscopy. Conformational exchange caused by a rotation of 2-nytrophenyl group around one single ...
<sup>1</sup>H NMR Characterization of Two New Pyridoxine Derivatives

Rakhmatullin I.; Galiullina L.; Garipov M.; Strel’nik A.; Shtyrlin Y.; Klochkov V. (2016)

© 2016, Springer Science+Business Media New York.Two new pyridoxine derivatives were studied by dynamic 1H NMR spectroscopy. The complete 1H NMR data for two pyridoxine derivatives are presented. Assignment of the signals ...
Synthesis and antibacterial activity of novel phosphonium salts on the basis of pyridoxine

Pugachev M.; Shtyrlin N.; Sysoeva L.; Nikitina E.; Abdullin T.; Iksanova A.; Ilaeva A.; Musin R.; Berdnikov E.; Shtyrlin Y. (2013)

A series of 13 phosphonium salts on the basis of pyridoxine derivatives were synthesized and their antibacterial activity against clinically relevant strains was tested in vitro. All compounds were almost inactive against ...
Synthesis and antibacterial activity of novel quaternary ammonium pyridoxine derivatives

Shtyrlin N.; Sapozhnikov S.; Koshkin S.; Iksanova A.; Sabirov A.; Kayumov A.; Nureeva A.; Zeldi M.; Shtyrlin Y. (2015)

© 2015 Bentham Science Publishers. A series of 26 quaternary ammonium pyridoxine derivatives were synthesized and their cytotoxicity and antibacterial activities against clinically relevant bacterial strains were tested ...
Synthesis and antimicrobial activity of adamantyl substituted pyridoxine derivatives

Khaziev R.; Shtyrlin N.; Pavelyev R.; Nigmatullin R.; Gabbasova R.; Grishaev D.; Shtro A.; Galochkina A.; Nikolaeva Y.; Vinogradova T.; Manicheva O.; Dogonadze M.; Gnezdilov O.; Sokolovich E.; Yablonskiy P.; Balakin K.; Shtyrlin Y. (2019)

© 2019 Bentham Science Publishers Background: Adamantane derivatives possess multiple pharmacological activities such as antiviral, anticancer, antimycobacterial, antidiabetic, antiparkinsonian and others. The interest of ...
Synthesis and antitumor activity of novel pyridoxine-based structural analogs of saccharumoside-B

Pugachev M.V.; Agafonova M.N.; Bastrikova O.A.; Gnezdilov O.I.; Nikishova T.V.; Balakin K.V.; Shtyrlin Y.G. (2021)

A series of 11 new pyridoxine-based structural analogs of saccharumoside-B were obtained using original synthetic approach. Antitumor activity of these compounds against nine human tumor cell lines (MCF-7, MDA-MB-231, ...
Synthesis and characterization of pyridoxine, nicotine and nicotinamide salts of dithiophosphoric acids as antibacterial agents against resistant wound infection

Dang T.; Nizamov I.; Salikhov R.; Sabirzyanova L.; Vorobev V.; Burganova T.; Shaidoullina M.; Batyeva E.; Cherkasov R.; Abdullin T. (2019)

© 2018 Elsevier Ltd The pyridine-derived biomolecules are of considerable interest in developing medicinal compounds with various specific activities. Novel ammonium salts of pyridoxine, (S)-(–)-nicotine and nicotinamide ...
Synthesis and in vitro antitumor activity of novel alkenyl derivatives of pyridoxine, bioisosteric analogs of feruloyl methane

Pavelyev R.; Bondar O.; Nguyen T.; Ziganshina A.; Al Farroukh M.; Karwt R.; Alekbaeva G.; Pugachev M.; Yamaleeva Z.; Kataeva O.; Balakin K.; Shtyrlin Y. (2018)

© 2018 Elsevier Ltd Two series of novel pyridoxine-based azaheterocyclic analogs of feruloyl methane (Dehydrozingerone, DZG) were synthesized, and their biological activity against a panel of tumor and normal cell lines ...

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