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Browsing by Author "Nurullin L."

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Adrenoceptors at the Frog Neuromuscular Junction: an Immunohistochemical Study

Nurullin L.; Tyapkina O.; Malomouzh A. (2017)

© 2016, Springer Science+Business Media New York.Previously, it was shown that both adrenaline and noradrenaline potentiate neuromuscular transmission, but which one of the receptors mediates the facilitating effect of ...
Cholinergic nociceptive mechanisms in rat meninges and trigeminal Ganglia: Potential implications for migraine pain

Shelukhina I.; Mikhailov N.; Abushik P.; Nurullin L.; Nikolsky E.; Giniatullin R. (2017)

© 2017 Shelukhina, Mikhailov, Abushik, Nurullin, Nikolsky and Giniatullin.Background: Parasympathetic innervation of meninges and ability of carbachol, acetylcholine (ACh) receptor (AChR) agonist, to induce headaches ...
Cytoskeletal Protein Septins Participate in the Modulation of the Kinetics of Acetylcholine Quanta Release at Neuromuscular Junction

Khuzakhmetova V.; Nurullin L.; Bukharaeva E. (2016)

© 2016, Springer Science+Business Media New York.In the presynaptic nerve terminal, some families of cytoskeletal proteins can participate in the neurosecretion modulation. Septins, GTP-binding cytoskeletal proteins, form ...
Epidural stimulation combined with triple gene therapy for spinal cord injury treatment

Islamov R.; Bashirov F.; Fadeev F.; Shevchenko R.; Izmailov A.; Markosyan V.; Sokolov M.; Kuznetsov M.; Davleeva M.; Garifulin R.; Salafutdinov I.; Nurullin L.; Chelyshev Y.; Lavrov I. (2020)

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The translation of new therapies for spinal cord injury to clinical trials can be facilitated with large animal models close in morpho-physiological scale to humans. ...
Genome-wide atlas of promoter expression reveals contribution of transcribed regulatory elements to genetic control of disuse-mediated atrophy of skeletal muscle

Pintus S.S.; Akberdin I.R.; Yevshin I.; Makhnovskii P.; Tyapkina O.; Nigmetzyanov I.; Nurullin L.; Devyatiyarov R.; Shagimardanova E.; Popov D.; Kolpakov F.A.; Gusev O.; Gazizova G.R. (2021)

The prevention of muscle atrophy carries with it clinical significance for the control of increased morbidity and mortality following physical inactivity. While major transcriptional events associated with muscle ...
Immunohistochemical evidence of the presence of metabotropic receptors for γ-aminobutyric acid at the rat neuromuscular junctions

Malomuzh A.; Nurullin L.; Nikolsky E. (2015)

© 2015, Pleiades Publishing, Ltd. in the synapses of the “fast” (m. EDL) and “slow” (m. soleus) skeletal muscles of the rat GABA<inf>B</inf>R1 and GABA<inf>B</inf>R2 subunits of metabotropic receptors for γ-aminobutyric ...
Immunohistochemical research of reaction of motoneurons of lumbar spinal cord of the mice that were in 30-day flight on the BION-M1 biosatellite on a week readaptation to conditions of Earth gravitation

Tyapkina O.; Rezvyakov P.; Nurullin L.; Petrov K.; Nikolskiy E.; Islamov R. (2016)

© 2016, Human Stem Cell Institute. All rights reserved.Earlier, by an immunohistochemical method we define that after 30-day space flight in motoneurons of mice lumbar spinal cord immunoexpression of the proteins responsible ...
Involvement of dihydropyridine-sensitive calcium channels in high asynchrony of transmitter release in neuromuscular synapses of newborn rats

Khuzakhmetova V.; Nurullin L.; Bukharaeva E.; Nikolsky E. (2016)

© 2016, Pleiades Publishing, Ltd.Experiments on neuromuscular synapses of rats at different stages of ontogenesis have been performed. It has been found that one of the reasons of higher asynchrony of the release of single ...
Kinetics of neurotransmitter release in neuromuscular synapses of newborn and adult rats

Khuzakhmetova V.; Samigullin D.; Nurullin L.; Vyskočil F.; Nikolsky E.; Bukharaeva E. (2014)

The kinetics of the phasic synchronous and delayed asynchronous release of acetylcholine quanta was studied at the neuromuscular junctions of aging rats from infant to mature animals at various frequencies of rhythmic ...
Metabotropic and ionotropic glutamate receptors mediate the modulation of acetylcholine release at the frog neuromuscular junction

Tsentsevitsky A.; Nurullin L.; Nikolsky E.; Malomouzh A. (2017)

© 2016 Wiley Periodicals, Inc.There is some evidence that glutamate (Glu) acts as a signaling molecule at vertebrate neuromuscular junctions where acetylcholine (ACh) serves as a neurotransmitter. In this study, performed ...
Metabotropic GABAB receptors mediate GABA inhibition of acetylcholine release in the rat neuromuscular junction

Malomouzh A.; Petrov K.; Nurullin L.; Nikolsky E. (2015)

© 2015 International Society for Neurochemistry. Gamma-aminobutyric acid (GABA) is an amino acid which acts as a neurotransmitter in the central nervous system. Here, we studied the effects of GABA on non-quantal, spontaneous, ...
Muscarinic cholinoreceptors (M1-, M2-, M3- and M4-type) modulate the acetylcholine secretion in the frog neuromuscular junction

Tsentsevitsky A.; Kovyazina I.; Nurullin L.; Nikolsky E. (2017)

© 2017 Elsevier B.V.Muscarinic cholinoreceptors regulate the neurosecretion process in vertebrate neuromuscular junctions. The diversity of muscarinic effects on acetylcholine (ACh) secretion may be attributed to the ...
New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease

Zueva I.; Dias J.; Lushchekina S.; Semenov V.; Mukhamedyarov M.; Pashirova T.; Babaev V.; Nachon F.; Petrova N.; Nurullin L.; Zakharova L.; Ilyin V.; Masson P.; Petrov K. (2019)

© 2019 Elsevier Ltd Profound synaptic dysfunction contributes to early loss of short-term memory in Alzheimer's disease. This study was set up to analyze possible neuroprotective effects of two dual binding site inhibitors ...
Preventive triple gene therapy reduces the negative consequences of ischemia-induced brain injury after modelling stroke in a rat

Markosyan V.; Safiullov Z.; Izmailov A.; Fadeev F.; Sokolov M.; Kuznetsov M.; Trofimov D.; Kim E.; Kundakchyan G.; Gibadullin A.; Salafutdinov I.; Nurullin L.; Bashirov F.; Islamov R. (2020)

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Currently, the main fundamental and clinical interest for stroke therapy is focused on developing a neuroprotective treatment of a penumbra region within the ...
Reorganization of Septins Modulates Synaptic Transmission at Neuromuscular Junctions

Nurullin L.; Khuzakhmetova V.; Khaziev E.; Samigullin D.; Tsentsevitsky A.; Skorinkin A.; Bukharaeva E.; Vagin O. (2019)

© 2019 IBRO Septins (Sept) are highly conserved Guanosine-5'-triphosphate (GTP)-binding cytoskeletal proteins involved in neuronal signaling in the central nervous system but their involvement in signal transmission in ...
Schwann cells sense and control acetylcholine spillover at the neuromuscular junction by α7 nicotinic receptors and butyrylcholinesterase

Petrov K.; Girard E.; Nikitashina A.; Colasante C.; Bernard V.; Nurullin L.; Leroy J.; Samigullin D.; Colak O.; Nikolsky E.; Plaud B.; Krejci E. (2014)

Terminal Schwann cells (TSCs) are key components of the mammalian neuromuscular junction (NMJ). How the TSCs sense the synaptic activity in physiological conditions remains unclear. We have taken advantage of the distinct ...
Semaphorins Are Likely to Be Involved in the Control of Hibernation

Gazizova G.; Kozlova O.; Tyapkina O.; Nurullin L.; Shagimardanova E. (2017)

© 2016, Springer Science+Business Media New York.Hibernation is unique mammals’ phenotype demonstrated surviving in seasonal adverse environment conditions. During hibernation, all of systems of organs undergo alterations ...
Studies of the expression of subunits α2 and β1 of Na+/K+-ATPase, α1S (L-type) Ca2+-channel, and SERCA 1/2/3 of Ca2+-ATPase of phasic and postural rat muscles in a model of hypogravity using the method of fluorescent microscopy

Nurullin L.; Tyapkina O.; Volkov E. (2016)

© 2016, Pleiades Publishing, Ltd.Using fluorescent microscopy, we found decreased expression of the β1 subunit of Na+/K+-ATPase and subunits of Ca2+-ATPase, increased expression of the α1S subunit of the L-type Ca2+-channel, ...

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Browsing by Author "Nurullin L."

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