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Browsing by Author "Nagaswami C."

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Altered platelet and coagulation function in moderate-to-severe COVID-19

Litvinov R.I.; Evtugina N.G.; Peshkova A.D.; Safiullina S.I.; Andrianova I.A.; Khabirova A.I.; Nagaswami C.; Khismatullin R.R.; Sannikova S.S.; Weisel J.W. (2021)

To reveal if coagulopathies relate to the course of COVID-19, we examined 255 patients with moderate and severe COVID-19, receiving anticoagulants and immunosuppressive drugs. Coagulopathy manifested predominantly as ...
Circulating Microparticles Alter Formation, Structure, and Properties of Fibrin Clots

Zubairova L.; Nabiullina R.; Nagaswami C.; Zuev Y.; Mustafin I.; Litvinov R.; Weisel J. (2015)

Despite the importance of circulating microparticles in haemostasis and thrombosis, there is limited evidence for potential causative effects of naturally produced cell-derived microparticles on fibrin clot formation and ...
Morphometric characterization of fibrinogen's αc regions and their role in fibrin self-assembly and molecular organization

Protopopova A.; Litvinov R.; Galanakis D.; Nagaswami C.; Barinov N.; Mukhitov A.; Klinov D.; Weisel J. (2017)

© 2017 The Royal Society of Chemistry. The flexible C-terminal parts of fibrinogen's Aα chains named the αC regions have been shown to play a role in fibrin self-assembly, although many aspects of their structure and ...
Neutrophil a-defensins promote thrombosis in vivo by altering fibrin formation, structure, and stability

Abu-Fanne R.; Stepanova V.; Litvinov R.; Abdeen S.; Bdeir K.; Higazi M.; Maraga E.; Nagaswami C.; Mukhitov A.; Weisel J.; Cines D.; Higazi A. (2019)

© 2019 by The American Society of Hematology. Inflammation and thrombosis are integrated, mutually reinforcing processes, but the interregulatory mechanisms are incompletely defined. Here, we examined the contribution of ...
Pathologically stiff erythrocytes impede contraction of blood clots

Tutwiler V.; Litvinov R.I.; Protopopova A.; Nagaswami C.; Villa C.; Woods E.; Abdulmalik O.; Siegel D.L.; Russell J.E.; Muzykantov V.R.; Lam W.A.; Myers D.R.; Weisel J.W. (2021)

Background: Blood clot contraction, volume shrinkage of the clot, is driven by platelet contraction and accompanied by compaction of the erythrocytes and their gradual shape change from biconcave to polyhedral, with the ...
Pathology of lung-specific thrombosis and inflammation in COVID-19

Khismatullin R.R.; Ponomareva A.A.; Nagaswami C.; Ivaeva R.A.; Montone K.T.; Weisel J.W.; Litvinov R.I. (2021)

Background: Infection by SARS-CoV-2 produces significant pulmonary pathology including endothelial damage with resultant thrombotic events. While pathologic features were described, there are limited data on the relationship ...
Quantitative Morphology of Cerebral Thrombi Related to Intravital Contraction and Clinical Features of Ischemic Stroke

Khismatullin R.R.; Nagaswami C.; Shakirova A.Z.; Vrtková A.; Procházka V.; Gumulec J.; Mačák J.; Litvinov R.I.; Weisel J.W. (2020)

© 2020 Lippincott Williams and Wilkins. All rights reserved. Background and Purpose: The purpose was to assess quantitatively and qualitatively the composition and structure of cerebral thrombi and correlate them with the ...
Shape changes of erythrocytes during blood clot contraction and the structure of polyhedrocytes

Tutwiler V.; Mukhitov A.; Peshkova A.; Le Minh G.; Khismatullin R.; Vicksman J.; Nagaswami C.; Litvinov R.; Weisel J. (2018)

© 2018, The Author(s). Polyhedral erythrocytes, named polyhedrocytes, are formed in contracted blood clots and thrombi, as a result of compression by activated contractile platelets pulling on fibrin. This deformation was ...
The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli

Chernysh I.N.; Nagaswami C.; Kosolapova S.; Peshkova A.D.; Cuker A.; Cines D.B.; Cambor C.L.; Litvinov R.I.; Weisel J.W. (2020)

© 2020, The Author(s). Although arterial and venous thromboembolic disorders are among the most frequent causes of mortality and morbidity, there has been little description of how the composition of thrombi and emboli ...

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Browsing by Author "Nagaswami C."

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