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  • ARID1A spatially partitions interphase chromosomes 
    Wu S.; Fatkhutdinov N.; Rosin L.; Luppino J.; Iwasaki O.; Tanizawa H.; Tang H.; Kossenkov A.; Gardini A.; Noma K.; Speicher D.; Joyce E.; Zhang R. (2019)
    © 2019 by the Authors. ARID1A, a subunit of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex, localizes to both promoters and enhancers to influence transcription. However, the role of ARID1A in ...
  • BET Bromodomain Inhibition Synergizes with PARP Inhibitor in Epithelial Ovarian Cancer 
    Karakashev S.; Zhu H.; Yokoyama Y.; Zhao B.; Fatkhutdinov N.; Kossenkov A.; Wilson A.; Simpkins F.; Speicher D.; Khabele D.; Bitler B.; Zhang R. (2017)
    © 2017 The Author(s) PARP inhibition is known to be an effective clinical strategy in BRCA mutant cancers, but PARP inhibition has not been applied to BRCA-proficient tumors. Here, we show the synergy of BET bromodomain ...
  • HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci 
    Aird K.; Iwasaki O.; Kossenkov A.; Tanizawa H.; Fatkhutdinov N.; Bitler B.; Le L.; Alicea G.; Yang T.; Johnson F.; Noma K.; Zhang R. (2016)
    Cellular senescence is a stable cell growth arrest that is characterized by the silencing of proliferation-promoting genes through compaction of chromosomes into senescence-associated heterochromatin foci (SAHF). Paradoxically, ...
  • N<sup>6</sup>-methylation of adenosine of FZD10 mRNA contributes to PARP inhibitor resistance 
    Fukumoto T.; Zhu H.; Nacarelli T.; Karakashev S.; Fatkhutdinov N.; Wu S.; Liu P.; Kossenkov A.; Showe L.; Jean S.; Zhang L.; Zhang R. (2019)
    © 2019 American Association for Cancer Research. Despite the high initial response rates to PARP inhibitors (PARPi) in BRCA-mutated epithelial ovarian cancers (EOC), PARPi resistance remains a major challenge. Chemical ...
  • SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells 
    Wu S.; Fatkhutdinov N.; Fukumoto T.; Bitler B.; Park P.; Kossenkov A.; Trizzino M.; Tang H.; Zhang L.; Gardini A.; Speicher D.; Zhang R. (2018)
    © 2018, The Author(s). Inactivation of the subunits of SWI/SNF complex such as ARID1A is synthetically lethal with inhibition of EZH2 activity. However, mechanisms of de novo resistance to EZH2 inhibitors in cancers with ...

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