Browsing by Author "Karakashev S."

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  • BET Bromodomain Inhibition Synergizes with PARP Inhibitor in Epithelial Ovarian Cancer 
    Karakashev S.; Zhu H.; Yokoyama Y.; Zhao B.; Fatkhutdinov N.; Kossenkov A.; Wilson A.; Simpkins F.; Speicher D.; Khabele D.; Bitler B.; Zhang R. (2017)
    © 2017 The Author(s) PARP inhibition is known to be an effective clinical strategy in BRCA mutant cancers, but PARP inhibition has not been applied to BRCA-proficient tumors. Here, we show the synergy of BET bromodomain ...
  • N<sup>6</sup>-methylation of adenosine of FZD10 mRNA contributes to PARP inhibitor resistance 
    Fukumoto T.; Zhu H.; Nacarelli T.; Karakashev S.; Fatkhutdinov N.; Wu S.; Liu P.; Kossenkov A.; Showe L.; Jean S.; Zhang L.; Zhang R. (2019)
    © 2019 American Association for Cancer Research. Despite the high initial response rates to PARP inhibitors (PARPi) in BRCA-mutated epithelial ovarian cancers (EOC), PARPi resistance remains a major challenge. Chemical ...

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