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Browsing by Author "Kaligin M."

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Analysis of recombinant VEGF gene expression by genetically modified umbilical cord blood mononuclear cells in experiment in vivo

Mukhamedshina Y.; Solovieva V.; Salafutdinov I.; Cherenkova E.; Fedotova V.; Safiullov Z.; Izmailov A.; Sharifullina G.; Abdulhakov S.; Kaligin M.; Bashirov F.; Muhamediarov M.; Shmarov M.; Naroditskii B.; Kiiasov A.; Rizvanov A.; Islamov R. (2012)

To obtain a significant therapeutic effect transplanted genetically modified cells should have an enhanced ability to survive and active expression of the therapeutic gene. In this paper, by using immunofluorescent staining ...
Analysis of the efficiency of gene-cell therapy in transgenic mice with amyotrophic lateral sclerosis phenotype

Mukhamedyarov M.; Rizvanov A.; Safiullov Z.; Izmailov A.; Sharifullina G.; Solovieva V.; Fedotova V.; Salafutdinov I.; Cherenkova E.; Bashirov F.; Kaligin M.; Abdulkhakov S.; Shmarov M.; Logunov D.; Naroditsky B.; Kiyasov A.; Zefirov A.; Islamov R. (2013)

Amyotrophic lateral sclerosis is a neurodegenerative disease characterized by progressive death of cerebral and spinal motorneurons. Using behavioral tests we studied the efficiency of gene-cell therapy in SOD1 G93A ...
C-kit and desmin-positive cells in expression in islets of pancreas during alloxan diabetes in rats.

Kaligin M.; Plushkina A.; Titova A.; Titova M.; Gumerova A.; Kiassov A. (2013)

Nowadays there are findings that C-kit-positive and desmin-positive stellate cells help to regenerate endocrine part of pancreas. But still it is unknown about their role and the way of differentiation of these cells during ...
C-kit-positive pancreas islets cell of rats pancreas as a endocrine cells progenitor during alloxan diabetes

Plushkina A.; Kaligin M.; Andreeva D.; Titova A.; Valeeva I.; Demyanov A.; Gumerova A.; Kiassov A. (2012)

One of the most common markers for stem cells in pancreas is the stem cell factor receptor C-kit (CD117) that plays a main role in differentiation of progenitor endocrine cells of pancreas islets in prenatal development ...
C-kit-positive progenitor cells activation in rats pancreas after partial hepatectomy

Kaligin M.; Plushkina A.; Gazizov I.; Sharipova E.; Gymerova A.; Kiassov A. (2012)

One of the most common markers of pancreas stem cells is a stem cell factor receptor C-kit. According to some authors, this marker is presented in islet cells of normal rat pancreas. But it is unknown about the behavior ...
Changes of liver microstructure after partial hepatectomy in rats

Gazizov I.; Kaligin M.; Andreeva D.; Yilmaz T.; Gumerova A.; Kiassov A. (2013)

Ability of mammalian liver to regenerate is one of the favorite examples of "regenerative medicine". At the same time liver regeneration can not be viewed as a simple hypertrophy, it must have some appropriate steps. ...
Comparison of different methods of rat hepatic stellate cells isolation, labeling and transplantation

Shafigullina A.; Trondin A.; Burganova G.; Titova A.; Mavlikeev M.; Sharipova E.; Tabanakova A.; Gazizov I.; Kaligin M.; Titova M.; Rizvanov A.; Gumerova A.; Kiassov A. (2013)

Nowadays more and more attention is turned to hepatic stellate cells (HSC) and their role in liver regeneration. Nonetheless there are several methodological questions, for example, methods of HSC isolation, their labeling ...
Effects of Transplanted Umbilical Cord Blood Mononuclear Cells Overexpressing GDNF on Spatial Memory and Hippocampal Synaptic Proteins in a Mouse Model of Alzheimer's Disease

Petukhova E.; Mukhamedshina Y.; Salafutdinov I.; Garanina E.; Kaligin M.; Leushina A.; Rizvanov A.; Reis H.; Palotás A.; Zefirov A.; Mukhamedyarov M. (2019)

© 2019 - IOS Press and the authors. All rights reserved. Background/Objective: Alzheimer's disease (AD) is a progressive incurable neurodegenerative disorder. Glial cell line-derived neurotrophic factor (GDNF) is a prominent ...
Genetically modified human umbilical cord blood cells expressing vascular endothelial growth factor and fibroblast growth factor 2 differentiate into glial cells after transplantation into amyotrophic lateral sclerosis transgenic mice

Rizvanov A.; Guseva D.; Salafutdinov I.; Kudryashova N.; Bashirov F.; Kiyasov A.; Yalvaç M.; Gazizov I.; Kaligin M.; Sahin F.; Mukhamedyarov M.; Palotás A.; Islamov R. (2011)

Current therapy of a number of neuropsychiatric maladies has only symptomatic modality. Effective treatment of these neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), may benefit from combined ...
Hepatic stellate cells stimulate liver regeneration after partial hepatectomy under inhibition of hepatocyte proliferation

Titova A.; Burganova G.; Sharipova E.; Pevnev G.; Mavlikeev M.; Gazizov I.; Galyavieva A.; Shafigullina A.; Kaligin M.; Titova M.; Gumerova A.; Kiassov A. (2014)

Most of the fundamental studies in the field of developing new methods for treating liver diseases in regenerative medicine are performed with haematopoietic and mesenchymal stem cells. At the same time more and more ...
Human umbilical cord blood cells transfected with VEGF and L1CAM do not differentiate into neurons but transform into vascular endothelial cells and secrete neuro-trophic factors to support neuro-genesis-a novel approach in stem cell therapy

Rizvanov A.; Kiyasov A.; Gaziziov I.; Yilmaz T.; Kaligin M.; Andreeva D.; Shafigullina A.; Guseva D.; Kiselev S.; Matin K.; Palotás A.; Islamov R. (2008)

Genetically modified mono-nuclear cell fraction from human umbilical cord blood (HUCB) expressing human vascular endothelial growth factor (VEGF) and mouse neural L1 cell adhesion molecule (L1CAM) were used for gene-stem ...
Intravenous Transplantation of Human Umbilical Cord Blood Mononuclear Cells Overexpressing Nerve Growth Factor Improves Spatial Memory in APP/PS1 Transgenic Mice with a Model of Alzheimer’s Disease

Kaligin M.; Mukhamedshina Y.; Rizvanov A.; Zefirov A.; Islamov R. (2018)

© 2017, Springer Science+Business Media, LLC, part of Springer Nature. Alzheimer’s disease is a progressive incurable neurodegenerative disease manifested by dementia and other cognitive disorders. Gene-cell therapy is one ...
Population Dynamics of MafA-Positive Cells During Ontogeny of Human Pancreas

Kaligin M.; Pliushkina A.; Titova A.; Titova M.; Gumerova A.; Kiassov A. (2017)

© 2016, Springer Science+Business Media New York.Diverse transcription factors influencing cell differentiation are often chosen as markers of β cell progenitors. One of these transcription factors is MafA, which according ...
Possible directions of human cord blood mononuclear cells differentiation in the regenerating rat liver

Andreeva D.; Gazizov I.; Ylmaz T.; Kaligin M.; Gumerova A.; Kiyasov A. (2013)

It is known that human cord blood hematopoietic stem cells (HSC) are able to differentiate into hepatocytes. This ability can be widely used in treatment of various liver diseases. However, there are some genetic diseases ...
Transplanted hepatic stellate cells participate in liver regeneration after partial hepatectomy without risk of hepatic fibrosis

Shafigullina A.; Gumerova A.; Trondin A.; Titova M.; Gazizov I.; Burganova G.; Kaligin M.; Andreeva D.; Rizvanov A.; Muhamedov A.; Kiassov A. (2012)

Hepatic stellate cells are considered as one of the potential stem cells candidates in the liver. The aim of our work was to study the probability of hepatic stellate cells transplantation to rats after partial hepatectomy, ...

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Browsing by Author "Kaligin M."

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