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Просмотр по автору "James V."

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Analysis of the Interaction and Proliferative Activity of Adenocarcinoma, Peripheral Blood Mononuclear and Mesenchymal Stromal Cells after Co-Cultivation In Vitro

Kitaeva K.; Prudnikov T.; Gomzikova M.; Kletukhina S.; James V.; Rizvanov A.; Solovyeva V. (2019)

© 2019, Springer Science+Business Media, LLC, part of Springer Nature. The tumor microenvironment is a heterogeneous population of cells actively involved in the process of growth and development of a tumor. Research has ...
Analyzing the Effectiveness of Adipose Tissue Stem Cell and Microvesicle Therapy in Premature Skin Aging Caused by Chronic Exposure to Ultraviolet Radiation

Syromiatnikova V.; Idrisova K.; Masgutova G.; Gomzikova M.; Kabwe E.; Bek J.; Andreeva D.; Masgutov R.; Mullakhmetova A.; James V.; Rizvanov A. (2020)

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Adipose-derived mesenchymal stem cells (ADSCs) and microvesicles (MVs) isolated from ADSCs are promising therapeutic agents for various pathological ...
Blood serum cytokines in patients with subacute spinal cord injury: A pilot study to search for biomarkers of injury severity

Ogurcov S.; Shulman I.; Garanina E.; Sabirov D.; Baichurina I.; Kuznetcov M.; Masgutova G.; Kostennikov A.; Rizvanov A.; James V.; Mukhamedshina Y. (2021)

Background. Despite considerable interest in the search for a spinal cord injury (SCI) therapy, there is a critical need to develop a panel of diagnostic biomarkers to determine injury severity. In this regard, there is a ...
Cytochalasin B-Induced membrane vesicles from human mesenchymal stem cells overexpressing IL2 are able to stimulate CD8+ T-Killers to kill human triple negative breast cancer cells

Chulpanova D.S.; Gilazieva Z.E.; Kletukhina S.K.; Aimaletdinov A.M.; Garanina E.E.; James V.; Rizvanov A.A.; Solovyeva V.V. (2021)

Simple Summary: Almost all human cells release extracellular vesicles participating in intercellular communication. Extracellular vesicles are rounded structures surrounded by the cytoplasmic membrane, which embody cytoplasmic ...
Extracellular vesicles in the diagnosis and treatment of central nervous system diseases

Shaimardanova A.; Solovyeva V.; Chulpanova D.; James V.; Kitaeva K.; Rizvanov A. (2020)

© The Author(s) 2019. Published by Oxford University Press on behalf of the British Geriatrics Society. Extracellular vesicles, including exosomes and microvesicles, play a fundamental role in the activity of the nervous ...
Genetic Modification of Mesenchymal Stem Cells for Neurological Disease Therapy: What Effects Does it Have on Phenotype/Cell Behavior, Determining Their Effectiveness?

Ebrahim N.; James V.; Rizvanov A.A.; Mukhamedshina Y. (2020)

© 2020, Springer Nature Switzerland AG. Mesenchymal stem cells are a promising tool in regenerative medicine, and their functions can be enhanced through genetic modification. Recent advances in genetic engineering provide ...
Human mesenchymal stem cells overexpressing interleukin 2 can suppress proliferation of neuroblastoma cells in co-culture and activate mononuclear cells in vitro

Chulpanova D.S.; Solovyeva V.V.; James V.; Arkhipova S.S.; Gomzikova M.O.; Garanina E.E.; Akhmetzyanova E.R.; Tazetdinova L.G.; Khaiboullina S.F.; Rizvanov A.A. (2020)

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. High-dose recombinant interleukin 2 (IL2) therapy has been shown to be successful in renal cell carcinoma and metastatic melanoma. However, systemic administration ...
Mesenchymal stem cell therapy for spinal cord contusion: A comparative study on small and large animal models

Mukhamedshina Y.; Shulman I.; Ogurcov S.; Kostennikov A.; Zakirova E.; Akhmetzyanova E.; Rogozhin A.; Masgutova G.; James V.; Masgutov R.; Lavrov I.; Rizvanov A. (2019)

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Here, we provide a first comparative study of the therapeutic potential of allogeneic mesenchymal stem cells derived from bone marrow (BM-MSCs), adipose tissue ...
Mitochondria Donation by Mesenchymal Stem Cells: Current Understanding and Mitochondria Transplantation Strategies

Gomzikova M.O.; James V.; Rizvanov A.A. (2021)

The phenomenon of mitochondria donation is found in various tissues of humans and animals and is attracting increasing attention. To date, numerous studies have described the transfer of mitochondria from stem cells to ...
Role of mesenchymal stem cell-derived extracellular vesicles in epithelial-mesenchymal transition

Kletukhina S.; Neustroeva O.; James V.; Rizvanov A.; Gomzikova M. (2019)

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Epithelial-mesenchymal transition (EMT) is a process that takes place during embryonic development, wound healing, and under some pathological processes, including ...
Storage stability and delivery potential of cytochalasin B induced membrane vesicles

Kletukhina S.K.; Neustroeva O.A.; Kurbangaleeva S.V.; Salafutdinov I.I.; Rogov A.M.; James V.; Rizvanov A.A.; Gomzikova M.O. (2021)

Cell-free therapies based on extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) are considered as a promising tool for stimulating regeneration and immunomodulation. The need to develop a practical ...
The Function of NG2/CSPG4-expressing Cells in the Rat Spinal Cord Injury: An Immunoelectron Microscopy Study

Kabdesh I.M.; Arkhipova S.S.; Mukhamedshina Y.O.; James V.; Rizvanov A.A.; Chelyshev Y.A. (2021)

Emerging evidence supports an increased role for NG2/CSPG4-expressing cells in the process of neuroregeneration and synaptic plasticity, due to the increased production of multifunctional chondroitin sulfate proteoglycan ...
Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation

Gomzikova M.; James V.; Rizvanov A. (2019)

© Copyright © 2019 Gomzikova, James and Rizvanov. The immunosuppressive potential of mesenchymal stem cells has been extensively investigated in many studies in vivo and in vitro. In recent years, a variety preclinical and ...

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