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Browsing by Author "Iksanova A."

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Antioxidative vs cytotoxic activities of organotin complexes bearing 2,6-di-tert-butylphenol moieties

Antonenko T.; Shpakovsky D.; Vorobyov M.; Gracheva Y.; Kharitonashvili E.; Dubova L.; Shevtsova E.; Tafeenko V.; Aslanov L.; Iksanova A.; Shtyrlin Y.; Milaeva E. (2018)

Copyright © 2018 John Wiley & Sons, Ltd. Two series of organotin(IV) complexes with Sn–S bonds on the base of 2,6-di-tert-butyl-4-mercaptophenol (L1SH) of formulae Me2Sn(L1S)2 (1); Et2Sn(L1S)2 (2); Bu2Sn(L1S)2 (3); ...
Bis-phosphonium salts of pyridoxine: The relationship between structure and antibacterial activity

Pugachev M.; Shtyrlin N.; Sapozhnikov S.; Sysoeva L.; Iksanova A.; Nikitina E.; Musin R.; Lodochnikova O.; Berdnikov E.; Shtyrlin Y. (2013)

A series of 23 novel bis-phosphonium salts based on pyridoxine were synthesized and their antibacterial activities were evaluated in vitro. All compounds were inactive against gram-negative bacteria and exhibited the ...
Chemistry of pyridoxine in drug design

Shtyrlin Y.; Petukhov A.; Strelnik A.; Shtyrlin N.; Iksanova A.; Pugachev M.; Pavelyev R.; Dzyurkevich M.; Garipov M.; Balakin K. (2019)

© 2019, Springer Science+Business Media, Inc. Pyridoxine and its derivatives, pyridoxamine and pyridoxal, are the three main forms of vitamin B6, which play exceptionally important biological roles in living organisms. The ...
New quaternary ammonium pyridoxine derivatives: synthesis and antibacterial activity

Sapozhnikov S.; Shtyrlin N.; Kayumov A.; Zamaldinova A.; Iksanova A.; Nikitina Е.; Krylova Е.; Grishaev D.; Balakin K.; Shtyrlin Y. (2017)

© 2017, Springer Science+Business Media, LLC. A diverse library of 34 new quaternary mono-ammonium and bis-ammonium pyridoxine derivatives was synthesized, and their antibacterial activity against several clinically relevant ...
Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus

Dzyurkevich M.; Babkov D.; Shtyrlin N.; Mayka O.; Iksanova A.; Vassiliev P.; Balakin K.; Spasov A.; Tarasov V.; Barreto G.; Shtyrlin Y.; Aliev G. (2017)

© 2017 The Author(s). Glucokinase is one of the promising targets for glucose-lowering agents, and the development of GK activators are now considered as one of the most promising strategies for the treatment of type 2 ...
Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine

Pavelyev R.; Khairullina R.; Koshkin S.; Iksanova A.; Lodochnikova O.; Khaertdinov N.; Sitdikova G.; Safina A.; Aleksandrova E.; Ziganshina L.; Shtyrlin Y. (2016)

© 2016, Springer Science+Business Media New York.An approach to the synthesis of epoxides based on 6-hydroxymethylpyridoxine acetals was developed. The epoxides obtained were involved in the ring opening reactions by ...
Synthesis and antibacterial activity of novel phosphonium salts on the basis of pyridoxine

Pugachev M.; Shtyrlin N.; Sysoeva L.; Nikitina E.; Abdullin T.; Iksanova A.; Ilaeva A.; Musin R.; Berdnikov E.; Shtyrlin Y. (2013)

A series of 13 phosphonium salts on the basis of pyridoxine derivatives were synthesized and their antibacterial activity against clinically relevant strains was tested in vitro. All compounds were almost inactive against ...
Synthesis and antibacterial activity of novel quaternary ammonium pyridoxine derivatives

Shtyrlin N.; Sapozhnikov S.; Koshkin S.; Iksanova A.; Sabirov A.; Kayumov A.; Nureeva A.; Zeldi M.; Shtyrlin Y. (2015)

© 2015 Bentham Science Publishers. A series of 26 quaternary ammonium pyridoxine derivatives were synthesized and their cytotoxicity and antibacterial activities against clinically relevant bacterial strains were tested ...
Synthesis and Antitumor Activity of Novel Pyridoxine-Based Bioisosteric Analogs of trans -Stilbenes

Pugachev M.; Nguyen T.; Bulatov T.; Pavelyev R.; Iksanova A.; Bondar O.; Balakin K.; Shtyrlin Y. (2017)

© 2017 Mikhail V. Pugachev et al. A series of trans-6-phenylethenyl substituted pyridoxine derivatives, novel bioisosteric analogs of drugs based on trans-stilbene scaffold, were synthesized using the Wittig reaction of a ...
Synthesis and antitumor activity of pyridoxine monoalkenyl derivatives

Pugachev M.; Pavelyev R.; Nguyen T.; Iksanova A.; Lodochnikova O.; Shtyrlin Y. (2016)

© 2016, Springer Science+Business Media New York.A convenient method for the synthesis of pyridoxine alkenyl derivatives by the Wittig reaction of [(2,8-dimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl]triphenylphosphonium ...
Synthesis and biological activity of quaternary phosphonium salts based on 3-hydroxypyridine and 4-deoxypyridoxine

Shtyrlin N.; Vafina R.; Pugachev M.; Khaziev R.; Nikitina E.; Zeldi M.; Iksanova A.; Shtyrlin Y. (2016)

© 2016, Springer Science+Business Media New York.Methods for the synthesis of quaternary phosphonium salts based on 3-hydroxypyridine and 4-deoxypyridoxine were developed. Some of obtained compounds possess high antibacterial ...

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