Browsing by Author "Grigor’eva L.R."

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Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria

Tsepaeva O.V.; Salikhova T.I.; Grigor’eva L.R.; Ponomaryov D.V.; Dang T.; Ishkaeva R.A.; Abdullin T.I.; Nemtarev A.V.; Mironov V.F. (2021)

Salicylic acid (SA) remains one of the most fruitful natural compounds to generate drug molecules with versatile activities. In this study, effective synthesis of SA and acetylsalicylic acid (ASA) derivatives with a carrier ...
Synthesis of C(28)-linker derivatives of betulinic acid bearing phosphonate group

Tsepaeva O.V.; Nemtarev A.V.; Grigor’eva L.R.; Mironov V.F. (2021)

A convenient method for the synthesis of C(28)-linker derivatives of triterpenoids containing a phosphonate group is presented. The method is based on the reaction of triterpenic acids (using betulinic acid as an example) ...
Synthesis, anticancer, and antibacterial activity of betulinic and betulonic acid C-28-triphenylphosphonium conjugates with variable alkyl linker length

Tsepaeva O.V.; Nemtarev A.V.; Salikhova T.I.; Abdullin T.I.; Grigor’eva L.R.; Khozyainova S.A.; Mironov V.F. (2020)

© 2020 Bentham Science Publishers. Background: Conjugation of triterpenoids such as betulinic acid 1 with the Triphenylphosphonium (TPP) group is a powerful approach to generating medicinal compounds. Their development ...

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